Linked Life Data

8334525

Source:http://linkedlifedata.com/resource/pubmed/id/8334525

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-8-26
pubmed:abstractText
The distribution of a tracer dose of the dopamine transport probe [3H]CFT ([3H]WIN 35,428; 2.5 nmol/kg) in brain was examined 90 min following intravenous administration to a mature (8 years, approximately) and an aged (> 20 years) squirrel (Saimiri sciureus) monkey. Ex vivo autoradiography revealed [3H]CFT labeling predominantly in dopamine-rich regions. The high striatum:cerebellum ratio, 5.6, compares favorably with other markers for dopamine systems. Ligand accumulation in striatum was substantially lower in the aged monkey compared with the younger adult monkey. The present findings support the use of the cocaine congener CFT for monitoring the dopamine transporter on dopamine nerve terminals by PET (positron emission tomography) imaging.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0006-8993
pubmed:author
pubmed:issnType
Print
pubmed:day
21
pubmed:volume
611
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
322-5
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[3H]CFT ([3H]WIN 35,428) accumulation in dopamine regions of monkey brain: comparison of a mature and an aged monkey.
pubmed:affiliation
Department of Psychiatry, Harvard Medical School, Southborough, MA.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, U.S. Gov't, P.H.S.