Linked Life Data

8333554

Source:http://linkedlifedata.com/resource/pubmed/id/8333554

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-8-13
pubmed:abstractText
We describe four patients with retroperitoneal liposarcomas undergoing myosarcomatous differentiation. The patients (two men and two women) were 47, 48, 68, and 72 years of age when first seen. The primary tumors were large retroperitoneal, well-differentiated liposarcomas, one featuring areas of dedifferentiation (without muscle elements). A myosarcomatous component became evident at the first recurrence in three cases and at the second recurrence in one. This component was always within dedifferentiated areas and in three of the cases coincided with the emergence of the latter. The muscle component had exclusively leiomyosarcomatous phenotype (alpha-smooth-muscle actin reactivity) in one case, exclusively rhabdomyosarcomatous phenotype (myoglobin reactivity) in two cases, and combined leiomyosarcomatous and rhabdomyosarcomatous phenotype (alpha-smooth-muscle actin and myoglobin) in one case. Ultrastructural studies of one of the tumors with a rhabdomyosarcomatous component revealed the presence of sarcomeres. Two patients died of extensive retroperitoneal disease, one patient died following the attempted removal of a recurrence, and one patient is alive and free of disease. These cases demonstrate that the dedifferentiated component of liposarcoma may exhibit a myosarcomatous component, a feature analogous to that previously described in dedifferentiated chondrosarcoma.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0147-5185
pubmed:author
pubmed:issnType
Print
pubmed:volume
17
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
546-56
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Divergent myosarcomatous differentiation in retroperitoneal liposarcoma.
pubmed:affiliation
Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY 10021.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Case Reports