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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
2
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pubmed:dateCreated |
1977-3-15
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pubmed:abstractText |
Cyclic somatostatin was administered intravenously (10 mug/min for 60 min) to 10 healthy overnight fasted (postabsorptive) subjects and to 5 healthy 60-h fasted subjects. In both groups, arterial insulin and glucagon fell 50% and splanchnic release of these hormones was inhibited. In the overnight fasted subjects splanchnic glucose output fell 70%, splanchnic uptake of lactate and pyruvate was unchanged, alanine uptake fell by 25%, and glycerol uptake rose more than twofold in parallel with an increase in arterial glycerol. In the 60-h fasted group splanchnic glucose output was less than 40% of that observed in the overnight fasted subjects. Somatostatin led to a further decrease (--70%) in glucose production. Splanchnic uptake of lactate and pyruvate fell by 30-40%, amino acid uptake was unchanged, while uptake of glycerol rose fivefold. Total uptake of glucose precursors thus exceeded the simultaneous glucose output by more than 200%. Splanchnic uptake of FFA rose fourfold during somatostatin while output of beta-hydroxybutyrate increased by 75%. Estimated hepatic blood flow fell 25-35% and returned to base line as soon as the somatostatin infusion ended. It is concluded that (a) somatostatin-induced hypoglucagonemia results in inhibition of splanchnic glucose output in glycogen-depleted, 60-h fasted subjects as well as in postabsorptive subjects, indicating an effect of glucagon on hepatic gluconeogenesis as well as glycogenolysis; (b) the glucagonsensitive step(s) in gluconeogenesis affected by somatostatin involves primarily intra-hepatic disposal rather than net hepatic uptake of glucose precursors; (c) splanchnic uptake of fatty acids and ketone output are increased in the face of combined insulin and glucagon deficiency; and (d) diminished splanchnic blood flow may contribute to some of the effects of somatostatin on splanchnic metabolism.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-1091266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-1113681,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-1140513,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-1213658,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-1248672,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-13464070,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-13821779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-14007241,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-14201551,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-16695286,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4125377,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4127645,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4291146,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4368634,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4430704,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4430728,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4436439,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4594711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4682131,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4771103,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4823929,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-4893149,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-5129319,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-5329335,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-5941744,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-804491,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-820717,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-946564,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-946565,
http://linkedlifedata.com/resource/pubmed/commentcorrection/833277-979638
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
59
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
299-307
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pubmed:dateRevised |
2011-11-17
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pubmed:meshHeading |
pubmed-meshheading:833277-Adult,
pubmed-meshheading:833277-Blood Glucose,
pubmed-meshheading:833277-Fasting,
pubmed-meshheading:833277-Fatty Acids, Nonesterified,
pubmed-meshheading:833277-Female,
pubmed-meshheading:833277-Glucagon,
pubmed-meshheading:833277-Gluconeogenesis,
pubmed-meshheading:833277-Glucose,
pubmed-meshheading:833277-Glycogen,
pubmed-meshheading:833277-Humans,
pubmed-meshheading:833277-Insulin,
pubmed-meshheading:833277-Lactates,
pubmed-meshheading:833277-Liver,
pubmed-meshheading:833277-Male,
pubmed-meshheading:833277-Pyruvates,
pubmed-meshheading:833277-Somatostatin
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pubmed:year |
1977
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pubmed:articleTitle |
Influence of somatostatin on splanchnic glucose metabolism in postabsorptive and 60-hour fasted humans.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.
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