| pubmed-article:8332497 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8332497 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:8332497 | lifeskim:mentions | umls-concept:C0063700 | lld:lifeskim |
| pubmed-article:8332497 | lifeskim:mentions | umls-concept:C0021467 | lld:lifeskim |
| pubmed-article:8332497 | lifeskim:mentions | umls-concept:C0040624 | lld:lifeskim |
| pubmed-article:8332497 | lifeskim:mentions | umls-concept:C0021469 | lld:lifeskim |
| pubmed-article:8332497 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:8332497 | lifeskim:mentions | umls-concept:C1332838 | lld:lifeskim |
| pubmed-article:8332497 | pubmed:issue | 12 | lld:pubmed |
| pubmed-article:8332497 | pubmed:dateCreated | 1993-8-17 | lld:pubmed |
| pubmed-article:8332497 | pubmed:abstractText | Interferon regulatory factor 1 (IRF-1) is a DNA-binding factor which recognizes regulatory elements in the promoters of interferon (IFN)-beta and some IFN-inducible genes. We observed that expression of transfected murine IRF-1 in different mammalian cell lines leads to down-regulation or stop of proliferation depending on the extent of expression. Expression of fusion proteins composed of IRF-1 and the hormone binding domain of the human estrogen receptor does not exhibit IRF-1 activity in the absence of estrogen. However, after estrogen treatment of the cells IFN-beta promoters are activated and the cells stop growing. As shown by expression of IRF-1 mutants both functions of the IRF-1-protein require DNA-binding and transcriptional activation. Since secreted factors including IFNs are not responsible for the anti-proliferative effect of IRF-1 we suggest that IRF-1 may be regarded as a negative regulator of cell growth which acts by activation of down-stream effector genes. | lld:pubmed |
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| pubmed-article:8332497 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8332497 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8332497 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8332497 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8332497 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8332497 | pubmed:issn | 0305-1048 | lld:pubmed |
| pubmed-article:8332497 | pubmed:author | pubmed-author:HauserHH | lld:pubmed |
| pubmed-article:8332497 | pubmed:author | pubmed-author:KirchhoffSS | lld:pubmed |
| pubmed-article:8332497 | pubmed:author | pubmed-author:SchaperFF | lld:pubmed |
| pubmed-article:8332497 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8332497 | pubmed:day | 25 | lld:pubmed |
| pubmed-article:8332497 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:8332497 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8332497 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8332497 | pubmed:pagination | 2881-9 | lld:pubmed |
| pubmed-article:8332497 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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