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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
12
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pubmed:dateCreated |
1993-8-17
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pubmed:abstractText |
Interferon regulatory factor 1 (IRF-1) is a DNA-binding factor which recognizes regulatory elements in the promoters of interferon (IFN)-beta and some IFN-inducible genes. We observed that expression of transfected murine IRF-1 in different mammalian cell lines leads to down-regulation or stop of proliferation depending on the extent of expression. Expression of fusion proteins composed of IRF-1 and the hormone binding domain of the human estrogen receptor does not exhibit IRF-1 activity in the absence of estrogen. However, after estrogen treatment of the cells IFN-beta promoters are activated and the cells stop growing. As shown by expression of IRF-1 mutants both functions of the IRF-1-protein require DNA-binding and transcriptional activation. Since secreted factors including IFNs are not responsible for the anti-proliferative effect of IRF-1 we suggest that IRF-1 may be regarded as a negative regulator of cell growth which acts by activation of down-stream effector genes.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1324854,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1327748,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1371248,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1374362,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1376370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1382315,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1385455,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1390903,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-14056989,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1425595,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1442307,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1460054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1473147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1614874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1630447,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1667464,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1711219,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1718743,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1793735,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1886766,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1887237,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1907934,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1988150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-1988951,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2208287,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2246275,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2342456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2342469,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2460869,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2475256,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2481699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2504485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2557635,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2644044,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2662015,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2726461,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2726484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2744482,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-2911367,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3034597,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3126485,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3220255,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3390864,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3409321,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3714487,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3780678,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-3906652,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-4343525,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-4705382,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-6271971,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-6275366,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-7678054,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-7678055,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-7678339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-8417326,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-8438157,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8332497-8440236
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/DNA,
http://linkedlifedata.com/resource/pubmed/chemical/DNA-Binding Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/IRF1 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon Regulatory Factor-1,
http://linkedlifedata.com/resource/pubmed/chemical/Interferon-beta,
http://linkedlifedata.com/resource/pubmed/chemical/Irf1 protein, mouse,
http://linkedlifedata.com/resource/pubmed/chemical/Phosphoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Estrogen,
http://linkedlifedata.com/resource/pubmed/chemical/Recombinant Fusion Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Transcription Factors
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pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0305-1048
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
25
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pubmed:volume |
21
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
2881-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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