Linked Life Data

8332032

Source:http://linkedlifedata.com/resource/pubmed/id/8332032

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-8-17
pubmed:abstractText
To understand the effects of diabetes on vascular smooth muscle function and the underlying mechanisms involved, we examined the responses to noradrenaline (NA), serotonin, KCl and acetylcholine in the femoral artery of mongrel dogs with chronic diabetes (3 months)-induced subtotal pancreatectomy. Isolated ring segments of diabetic dog femoral artery exhibited an increased response to serotonin, a decreased response to NA, an unchanged response to KCl and a decreased endothelium-dependent relaxation to acetylcholine as compared with controls. The sensitivity (pD2) of diabetic femoral artery rings to NA and serotonin was markedly diminished. These results suggest that changed responsiveness of arteries from diabetic animals to NA, serotonin and acetylcholine could be the reflection of an alteration in the contractile machinery or the results of a decrease in endothelium-derived relaxing factor release in diabetic blood vessels.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0379-0355
pubmed:author
pubmed:issnType
Print
pubmed:volume
15
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
161-7
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of chronic experimental diabetes on vascular smooth muscle function in dog femoral artery.
pubmed:affiliation
Cumhuriyet University, Faculty of Medicine, Department of Pharmacology, Sivas, Turkey.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't