Linked Life Data

8331821

Source:http://linkedlifedata.com/resource/pubmed/id/8331821

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-8-17
pubmed:abstractText
Histopathological diffuse pallor of the cerebral white matter on myelin staining is a characteristic feature of progressive subcortical vascular encephalopathy of the Binswanger type (PSVE). However, the reason for the diffuse pallor was unclear. In a previous electron microscopic study the author reported that the number of nerve fibers per unit area of the frontal white matter was significantly less in PSVE than in the controls. The white matter pallor in PSVE is mainly related to the loss of nerve fibers there. Dementia in PSVE is probably related to the loss of nerve fibers in the cerebral white matter. The sum of the number of oligodendrocytes and astrocytes in the deep white matter in PSVE was approximately half of that in age-matched controls. The number of oligodendrocytes, which were defined as cells with small, round and solid nuclei, also decreased in PSVE being half of that in the deep white matter of the controls. These data suggest that the loss of oligodendrocytes and astrocytes plays a role in the process of nerve fibers loss in PSVE. Diffuse atherosclerotic lesions in the main stem of cerebral arteries and severe hyalinotic changes in the white matter arterioles are characteristic arterial lesions of PSVE. On the basis of severe arteriosclerosis in the cerebral arteries, it was speculated that repeated hypotension or greater variability of casual blood pressure could induce PSVE in the elderly hypertensives. To confirm the hypothesis, casual blood pressure in PSVE was retrospectively studied.(ABSTRACT TRUNCATED AT 250 WORDS)
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Mar
pubmed:issn
0300-9173
pubmed:author
pubmed:issnType
Print
pubmed:volume
30
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
193-7
pubmed:dateRevised
2011-7-29
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Progressive subcortical vascular encephalopathy of the Binswanger type (PSVE)].
pubmed:affiliation
Department of Neurology, Tokyo Metropolitan Geriatric Hospital.
pubmed:publicationType
Journal Article, English Abstract