Linked Life Data

8331533

Source:http://linkedlifedata.com/resource/pubmed/id/8331533

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-8-13
pubmed:abstractText
The chemical stability of ranitidine HCl in solution and in the solid state at various temperatures was investigated by high-performance liquid chromatography. Ranitidine HCl was unstable in lower pH buffer solutions, and the percent degradation after 72 h increased as the pH of the buffer solution was reduced. The percent degradation in the unbuffered solution increased dose dependently. The critical relative humidity (CRH) of the ranitidine HCl bulk powder was approximately 67% relative humidity (RH). The amount of water adsorbed onto the sample above the CRH was proportional to the RH level. The percent degradation of the powder below 50% RH was almost negligible because, at this level, it was a solid. The percent degradation at 60-70% RH was higher than that above 70% RH. Ranitidine HCl powder was unstable around the CRH.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0022-3549
pubmed:author
pubmed:issnType
Print
pubmed:volume
82
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
601-4
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effects of temperature and relative humidity on the solid-state chemical stability of ranitidine hydrochloride.
pubmed:affiliation
Department of Pharmaceutical Technology, Kobe Women's College of Pharmacy, Japan.
pubmed:publicationType
Journal Article