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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
786
|
| pubmed:dateCreated |
1993-8-17
|
| pubmed:abstractText |
This is a retrospective analysis of the long-term local control in 4128 patients with non-disseminated nasopharyngeal carcinoma treated solely by megavoltage irradiation during the years 1976-1985. The T-stage distribution according to Ho's classification was T1 37%, T2 14% and T3 49%. Different fractionation schedules had been employed at different periods, and the median dose to the primary target was equivalent to 65 Gy by time dose fractionation calculation. In 8% (344) of patients the tumour failed to regress completely after the basic course, but 89% (148/167) of those suitable for salvage with additional irradiation eventually attained complete local remission. The cumulative incidence of local failure was 24% (5% persistence, 19% recurrence). The 10-year actuarial local failure-free survival was 67%. While patients with T2 and T3a tumours achieved local control comparable to T1, those with T3c-d had the poorest control (with highest incidence of persistence and advanced recurrence). T-stage adjusted analyses suggested a significant trend of dose-response: the odds ratios for local failure were 1.16 and 1.86, respectively, when patients given 60-63 Gy and 55-59 Gy were compared with those given 64 Gy or above (p value = 0.0018). Patients treated during 1981-1985 achieved higher local failure-free survival than those treated during 1976-1980 (75% versus 70% at 5 years, p value = 0.0013). The possible attributes are studied, and ways for future optimization of treatment discussed.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
AIM
|
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0007-1285
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
66
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
528-36
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8330138-Adolescent,
pubmed-meshheading:8330138-Adult,
pubmed-meshheading:8330138-Aged,
pubmed-meshheading:8330138-Aged, 80 and over,
pubmed-meshheading:8330138-Child,
pubmed-meshheading:8330138-Dose-Response Relationship, Radiation,
pubmed-meshheading:8330138-Female,
pubmed-meshheading:8330138-Humans,
pubmed-meshheading:8330138-Male,
pubmed-meshheading:8330138-Middle Aged,
pubmed-meshheading:8330138-Nasopharyngeal Neoplasms,
pubmed-meshheading:8330138-Neoplasm Recurrence, Local,
pubmed-meshheading:8330138-Radiotherapy, High-Energy,
pubmed-meshheading:8330138-Retrospective Studies
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Nasopharyngeal carcinoma: local control by megavoltage irradiation.
|
| pubmed:affiliation |
Institute of Radiology and Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong.
|
| pubmed:publicationType |
Journal Article
|