Linked Life Data

8329469

Source:http://linkedlifedata.com/resource/pubmed/id/8329469

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1993-8-16
pubmed:abstractText
The preputial and clitoral glands of 111-114-week-old B6C3F1-mice from a carcinogenesis experiment showed histomorphological characteristics. The lesions were considered to be spontaneous age changes, because the type, incidence and severity do not distinguish treated animals from controls. The most common findings were atrophy of the acini, lymphocytic infiltrates and hyperplasia of the squamous cell epithelium. Less frequently abscesses, fibrosis following a possible inflammatory process, an increase in the amount of subepithelial connective tissue, cystic dilatation of the central duct or secondary malignant lymphocytic infiltration were found. Neoplasms were not diagnosed. Similar lesions were found in the preputial- and clitoral glands of untreated 75-week-old mice, which were investigated for comparison. No abnormal histomorphological findings were found in the glands of 10-week-old mice. Ultrastructural characteristics of the mouse preputial and clitoral glands are dense bodies in the cytoplasm and intramitochondrial granules, which decreases in number with age.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0939-8600
pubmed:author
pubmed:issnType
Print
pubmed:volume
35
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
166-76
pubmed:dateRevised
2003-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Histomorphological age changes and ultrastructural characteristics of the preputial and clitoral glands of mice.
pubmed:affiliation
Institute for Pathology and Toxicology, Byk Gulden Pharmaceuticals, Germany.
pubmed:publicationType
Journal Article