| pubmed-article:8329287 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8329287 | lifeskim:mentions | umls-concept:C0030705 | lld:lifeskim |
| pubmed-article:8329287 | lifeskim:mentions | umls-concept:C0003873 | lld:lifeskim |
| pubmed-article:8329287 | lifeskim:mentions | umls-concept:C0020740 | lld:lifeskim |
| pubmed-article:8329287 | lifeskim:mentions | umls-concept:C0743223 | lld:lifeskim |
| pubmed-article:8329287 | lifeskim:mentions | umls-concept:C2827666 | lld:lifeskim |
| pubmed-article:8329287 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:8329287 | pubmed:dateCreated | 1993-8-19 | lld:pubmed |
| pubmed-article:8329287 | pubmed:abstractText | 1. Patients suffering from rheumatoid arthritis received oral doses of 600 mg racemic ibuprofen (n = 25; RAC) or 400 mg (S)-ibuprofen (n = 25; S-IBU) in a double-blind, randomized parallel-group study. 2. The pharmacokinetic parameters of (S)-ibuprofen were not statistically different between treatments (P > 0.05). Comparing (S)- and (R)-ibuprofen within the group receiving the racemate significantly higher Cmax (20.3 +/- 5.3 vs 17.7 +/- 4.4 micrograms ml-1; P < 0.02; 95% confidence interval for differences (CI): 0.5-4.6), AUC (86.2 +/- 23.5 vs 67.6 +/- 26.6 micrograms ml-1 h; P < 0.001; CI: 9.5-27.6), mean residence time (4.5 +/- 1.1 vs 4.1 +/- 1.2 h; P < 0.01; CI: 0.1-0.6) and renal clearance (0.8 +/- 0.6 vs 0.0 +/- 0.0 ml min-1; P < 0.001; CI: 0.5-1.0) values were observed for the (S)-enantiomer. 3. No difference was found (P > 0.05) between treatments in the percentage of the dose recovered in the urine as (R)- or (S)-ibuprofen plus metabolites (S-IBU: 80.2 +/- 8.47 vs RAC: 74.1 +/- 14.0%). 4. Interindividual variation in the pharmacokinetics of (S)-ibuprofen following administration of the racemate was similar to that following the administration of the single isomer suggesting that chiral inversion is not a major factor contributing to variability in the disposition of this drug. | lld:pubmed |
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| pubmed-article:8329287 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8329287 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8329287 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8329287 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8329287 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8329287 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:8329287 | pubmed:issn | 0306-5251 | lld:pubmed |
| pubmed-article:8329287 | pubmed:author | pubmed-author:BruneKK | lld:pubmed |
| pubmed-article:8329287 | pubmed:author | pubmed-author:BachG LGL | lld:pubmed |
| pubmed-article:8329287 | pubmed:author | pubmed-author:LoewDD | lld:pubmed |
| pubmed-article:8329287 | pubmed:author | pubmed-author:GeisslingerGG | lld:pubmed |
| pubmed-article:8329287 | pubmed:author | pubmed-author:StockK PKP | lld:pubmed |
| pubmed-article:8329287 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8329287 | pubmed:volume | 35 | lld:pubmed |
| pubmed-article:8329287 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8329287 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8329287 | pubmed:pagination | 603-7 | lld:pubmed |
| pubmed-article:8329287 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:8329287 | pubmed:meshHeading | pubmed-meshheading:8329287-... | lld:pubmed |
| pubmed-article:8329287 | pubmed:meshHeading | pubmed-meshheading:8329287-... | lld:pubmed |
| pubmed-article:8329287 | pubmed:meshHeading | pubmed-meshheading:8329287-... | lld:pubmed |
| pubmed-article:8329287 | pubmed:meshHeading | pubmed-meshheading:8329287-... | lld:pubmed |
| pubmed-article:8329287 | pubmed:meshHeading | pubmed-meshheading:8329287-... | lld:pubmed |
| pubmed-article:8329287 | pubmed:meshHeading | pubmed-meshheading:8329287-... | lld:pubmed |
| pubmed-article:8329287 | pubmed:meshHeading | pubmed-meshheading:8329287-... | lld:pubmed |
| pubmed-article:8329287 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8329287 | pubmed:articleTitle | Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis. | lld:pubmed |
| pubmed-article:8329287 | pubmed:affiliation | Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuernberg, Germany. | lld:pubmed |
| pubmed-article:8329287 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8329287 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:8329287 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8329287 | pubmed:publicationType | Randomized Controlled Trial | lld:pubmed |
| pubmed-article:8329287 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
