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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
6
|
| pubmed:dateCreated |
1993-8-19
|
| pubmed:abstractText |
1. Patients suffering from rheumatoid arthritis received oral doses of 600 mg racemic ibuprofen (n = 25; RAC) or 400 mg (S)-ibuprofen (n = 25; S-IBU) in a double-blind, randomized parallel-group study. 2. The pharmacokinetic parameters of (S)-ibuprofen were not statistically different between treatments (P > 0.05). Comparing (S)- and (R)-ibuprofen within the group receiving the racemate significantly higher Cmax (20.3 +/- 5.3 vs 17.7 +/- 4.4 micrograms ml-1; P < 0.02; 95% confidence interval for differences (CI): 0.5-4.6), AUC (86.2 +/- 23.5 vs 67.6 +/- 26.6 micrograms ml-1 h; P < 0.001; CI: 9.5-27.6), mean residence time (4.5 +/- 1.1 vs 4.1 +/- 1.2 h; P < 0.01; CI: 0.1-0.6) and renal clearance (0.8 +/- 0.6 vs 0.0 +/- 0.0 ml min-1; P < 0.001; CI: 0.5-1.0) values were observed for the (S)-enantiomer. 3. No difference was found (P > 0.05) between treatments in the percentage of the dose recovered in the urine as (R)- or (S)-ibuprofen plus metabolites (S-IBU: 80.2 +/- 8.47 vs RAC: 74.1 +/- 14.0%). 4. Interindividual variation in the pharmacokinetics of (S)-ibuprofen following administration of the racemate was similar to that following the administration of the single isomer suggesting that chiral inversion is not a major factor contributing to variability in the disposition of this drug.
|
| pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-1762067,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-1784888,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-2083147,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-2379535,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-2724138,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-2775619,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-2777420,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-2793968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-2893700,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-3065056,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-3111512,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-3228575,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-3244607,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-3276314,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-3867269,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-4005104,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-6139449,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-6706,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8329287-6861443
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0306-5251
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
35
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
603-7
|
| pubmed:dateRevised |
2009-11-18
|
| pubmed:meshHeading | |
| pubmed:year |
1993
|
| pubmed:articleTitle |
Variability in the stereoselective disposition of ibuprofen in patients with rheumatoid arthritis.
|
| pubmed:affiliation |
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuernberg, Germany.
|
| pubmed:publicationType |
Journal Article,
Clinical Trial,
Comparative Study,
Randomized Controlled Trial,
Research Support, Non-U.S. Gov't
|