Linked Life Data

8329259

Source:http://linkedlifedata.com/resource/pubmed/id/8329259

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-8-17
pubmed:abstractText
We have compared the haemodynamic responses to i.v. propofol 2.5 mg kg-1 with those to thiopentone 5.0 mg kg-1 in 41 healthy Chinese children at induction of anaesthesia. They were allocated to four groups according to their age and induction agent received: group 1 < 2 yr, propofol, n = 9; group II < 2 yr, thiopentone, n = 9; group III 2-12 yr, propofol, n = 12; group IV 2-12 yr, thiopentone, n = 11. Anaesthesia was maintained by spontaneous ventilation with 70% nitrous oxide and 0.5% halothane in oxygen. Arterial pressure and heart rate were monitored by automatic oscillotonometer. Stroke volume was measured by two-dimensional echocardiography and pulse Doppler. Measurements were made before induction and at 1-min intervals for 5 min after induction. The reduction in mean arterial pressure was significantly greater after propofol (28-31%) than after thiopentone (14-21%) (P = 0.001). The reduction in cardiac index (10-15%) after induction was not significantly different between the two agents (P = 0.122). Baroreflex mediated increases in heart rate and systemic vascular resistance were less after propofol than after thiopentone. The baroreceptor reflex was more attenuated in children aged less than 2 yr than in older children.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0007-0912
pubmed:author
pubmed:issnType
Print
pubmed:volume
70
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
647-53
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Cardiovascular effects of i.v. induction in children: comparison between propofol and thiopentone.
pubmed:affiliation
Department of Anaesthesia and Intensive Care, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, New Territories.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial