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rdf:type |
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lifeskim:mentions |
umls-concept:C0004259,
umls-concept:C0020792,
umls-concept:C0204727,
umls-concept:C0205103,
umls-concept:C0205314,
umls-concept:C0205409,
umls-concept:C0243125,
umls-concept:C0521009,
umls-concept:C0660019,
umls-concept:C0679622,
umls-concept:C0699900
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pubmed:dateCreated |
1993-8-12
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pubmed:abstractText |
Growth of Pseudomonas AT3 on the alkaloid atropine as its sole source of carbon and nitrogen is nitrogen-limited and proceeds by degradation of the tropic acid part of the molecule, with the metabolism of the tropine being limited to the point of release of its nitrogen. A nitrogen-free compound accumulated in the growth medium and was isolated and identified as 6-hydroxycyclohepta-1,4-dione. This novel compound is proposed as an intermediate in tropine metabolism. It served as a growth substrate for the organism and was also the substrate for an NAD(+)-linked dehydrogenase present in cell extracts. The enzyme was induced during the tropine phase of diauxic growth on atropine or during growth on tropine alone.
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pubmed:commentsCorrections |
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0264-6021
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
293 ( Pt 1)
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
115-8
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
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pubmed:year |
1993
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pubmed:articleTitle |
The isolation and identification of 6-hydroxycyclohepta-1,4-dione as a novel intermediate in the bacterial degradation of atropine.
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pubmed:affiliation |
Department of Biochemistry, University of Wales, Aberystwyth, Dyfed, U.K.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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