Linked Life Data

8328802

Source:http://linkedlifedata.com/resource/pubmed/id/8328802

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-8-10
pubmed:abstractText
Under secondary metabolic conditions the white rot basidiomycete Phanerochaete chrysosporium rapidly mineralizes 2,4,5-trichlorophenol. The pathway for degradation of 2,4,5-trichlorophenol was elucidated by the characterization of fungal metabolites and oxidation products generated by purified lignin peroxidase (LiP) and manganese peroxidase (MnP). The multistep pathway involves cycles of peroxidase-catalyzed oxidative dechlorination reactions followed by quinone reduction reactions to yield the key intermediate 1,2,4,5-tetrahydroxybenzene, which is presumably ring cleaved. In the first step of the pathway, 2,4,5-trichlorophenol is oxidized to 2,5-dichloro-1,4-benzoquinone by either MnP or Lip. 2,5-Dichloro-1,4-benzoquinone is then reduced to 2,5-dichloro-1,4-hydroquinone. The 2,5-dichloro-1,4-hydroquinone is oxidized by MnP to generate 5-chloro-4-hydroxy-1,2-benzoquinone. The orthoquinone is in turn reduced to 5-chloro-1,2,4-trihydroxybenzene. Finally, the 5-chlorotrihydroxybenzene undergoes another cycle of oxidative dechlorination and reduction reactions to generate 1,2,4,5-tetrahydroxybenzene. The latter is presumably ring cleaved, with subsequent degradation to CO2. In this pathway, the substrate is oxidatively dechlorinated by LiP or MnP in a reaction which produces a quinone. The quinone intermediate is recycled by a reduction reaction to regenerate an intermediate which is again a substrate for peroxidase-catalyzed oxidative dechlorination. This pathway apparently results in the removal of all three chlorine atoms before ring cleavage occurs.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-1514787, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-1539977, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-1551837, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-16347375, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-16348355, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-1987125, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-2018522, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-2294087, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-2298739, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-2914954, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-3059995, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-3223759, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-3318677, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-4062285, http://linkedlifedata.com/resource/pubmed/commentcorrection/8328802-6497376
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0099-2240
pubmed:author
pubmed:issnType
Print
pubmed:volume
59
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1779-85
pubmed:dateRevised
2010-9-13
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Degradation of 2,4,5-trichlorophenol by the lignin-degrading basidiomycete Phanerochaete chrysosporium.
pubmed:affiliation
Department of Chemical and Biological Sciences, Oregon Graduate Institute of Science and Technology, Beaverton 97006-1999.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, Non-P.H.S., Research Support, Non-U.S. Gov't