Linked Life Data

8328334

Source:http://linkedlifedata.com/resource/pubmed/id/8328334

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
6
pubmed:dateCreated
1993-8-11
pubmed:abstractText
Endothelin (ET)-1, a potent vasoconstrictor which was discovered recently, might be involved in the regulation of ocular circulation. In this paper, we studied the effects of ET-1 on capillary blood flow of the optic nerve head and choroid in rabbits, using a hydrogen gas clearance flowmeter. Intravitreal injection of 0.1 ml of ET-1 at 10(-5) M and 10(-6) M caused a significant decrease in blood flow, which in the optic nerve head continued more than 3 hours, but in the choroid recovered at 3 hours after the injection (maximum decrease occurred at 75 minutes and at 30-60 minutes, respectively). Intraocular pressure was reduced as the time passed. Intravenous administration of 10(-10) mol/kg of ET-1 induced a reduction in blood flow, which in the optic nerve head continued more than 3 hours, but in the choroid recovered at 90 minutes after the administration. Intraocular pressure was reduced during 3 hours' observation. The decrease in blood flow in the optic nerve head was inhibited by previous administration of calcium antagonist (nicardipine), so the calcium channel was thought to be involved in this reaction.
pubmed:language
jpn
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0029-0203
pubmed:author
pubmed:issnType
Print
pubmed:volume
97
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
678-82
pubmed:dateRevised
2011-7-28
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
[Effect of endothelin-1 on ocular circulation].
pubmed:affiliation
Department of Ophthalmology, Osaka Medical College, Takatsuki, Japan.
pubmed:publicationType
Journal Article, English Abstract