Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
13
pubmed:dateCreated
1993-8-6
pubmed:databankReference
pubmed:abstractText
A series of translocation break points found in a subset of human acute leukemias have one of the breaks on human chromosome 11q23. This region has recently been cloned and a large gene, ALL-1, with homology to the Drosophila trithorax gene has been identified. This paper describes the cloning, sequencing, and mapping of the mouse homolog of ALL-1. We have found a motif present in All-1 that shows homology to the zinc-binding domain of DNA (cytosine-5) methyltransferases (EC 2.1.1.63). Sequence analysis of the murine All-1 gene has identified distinct regions of homology with the human ALL-1 gene; these highly conserved domains may define regions of functional significance in mammals. In addition, we have identified alternatively spliced forms of All-1 within one of the zinc-finger domains, suggesting that there may be different targets and/or functions for All-1 proteins. Finally, we report that All-1 resides in the proximal portion of mouse chromosome 9 and is a candidate for a mutation that results in skeletal transformations during embryonic development.
pubmed:grant
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1303259, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1321494, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1348969, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1353738, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1353951, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1423624, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1423625, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1465401, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1498428, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1572653, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1594447, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1617652, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1628623, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1658787, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1673105, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1692833, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1720549, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1835902, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1878967, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1968655, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-1996138, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-2000376, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-2107543, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-2244209, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-2251277, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-2331673, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-2527802, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-2759422, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-3210246, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-3248386, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-3488815, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-4093752, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-6546423, http://linkedlifedata.com/resource/pubmed/commentcorrection/8327517-8432536
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0027-8424
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
90
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
6350-4
pubmed:dateRevised
2009-11-18
pubmed:meshHeading
pubmed-meshheading:8327517-Humans, pubmed-meshheading:8327517-Animals, pubmed-meshheading:8327517-Mice, pubmed-meshheading:8327517-Base Sequence, pubmed-meshheading:8327517-Amino Acid Sequence, pubmed-meshheading:8327517-Chromosome Mapping, pubmed-meshheading:8327517-Molecular Sequence Data, pubmed-meshheading:8327517-Mice, Inbred C57BL, pubmed-meshheading:8327517-Precursor Cell Lymphoblastic Leukemia-Lymphoma, pubmed-meshheading:8327517-Methyltransferases, pubmed-meshheading:8327517-DNA-Binding Proteins, pubmed-meshheading:8327517-Transcription Factors, pubmed-meshheading:8327517-Chromosomes, Human, Pair 11, pubmed-meshheading:8327517-O(6)-Methylguanine-DNA Methyltransferase, pubmed-meshheading:8327517-Oncogenes, pubmed-meshheading:8327517-Proto-Oncogenes, pubmed-meshheading:8327517-Open Reading Frames, pubmed-meshheading:8327517-Conserved Sequence, pubmed-meshheading:8327517-Alternative Splicing
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