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rdf:type |
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lifeskim:mentions |
umls-concept:C0035366,
umls-concept:C0038078,
umls-concept:C0079411,
umls-concept:C0205214,
umls-concept:C0441712,
umls-concept:C0443203,
umls-concept:C0600399,
umls-concept:C0600455,
umls-concept:C0600477,
umls-concept:C1705920,
umls-concept:C1880022
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pubmed:issue |
13
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pubmed:dateCreated |
1993-8-6
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pubmed:databankReference |
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pubmed:abstractText |
Using labeled transcripts generated in vitro from squid total genomic DNA as a probe, we isolated and characterized a SINE that is present in the squid genome. The squid SINE appears to be derived from a tRNA(Lys). When the consensus sequences of five different SINEs with a tRNA(Lys)-like structure from distantly related species, including squid, were aligned, we found in the tRNA-unrelated region two sequence motifs that were almost identical among these five SINEs. This observation suggests a common evolutionary origin for these SINEs and/or some function(s) for these motifs. Similar sequences were unexpectedly found to be present in sequences complementary to the U5 regions of several mammalian retroviruses whose primer is a tRNA(Lys). On the basis of these findings, we present a model for the generation of SINEs. We propose that they are derived from a "strong-stop DNA" with a primer tRNA(Lys) that is an intermediate in the reverse transcription of certain retroviruses. Our model suggests that a certain group of SINEs may have been generated by horizontal transmission, although it is not clear whether information was transmitted via a similar retrovirus or via an RNA or DNA of a SINE.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1326298,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1379734,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1416250,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1517239,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1668310,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1691979,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1698615,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1702838,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-1848699,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2158181,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2183467,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2188136,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-225173,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2409043,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2421920,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2427017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2430260,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2435057,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2469098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2471077,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2472936,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2806917,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-2987967,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-3006247,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-3027401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-3455763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-3458171,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-3839306,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-3851163,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-3934392,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-6085956,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-6159101,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-6209580,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-6280868,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-6296779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-6314267,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8327507-6647031
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
90
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pubmed:geneSymbol |
SINE
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
6260-4
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pubmed:dateRevised |
2010-11-18
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pubmed:meshHeading |
pubmed-meshheading:8327507-Animals,
pubmed-meshheading:8327507-Base Sequence,
pubmed-meshheading:8327507-Biological Evolution,
pubmed-meshheading:8327507-Decapodiformes,
pubmed-meshheading:8327507-Genes,
pubmed-meshheading:8327507-Models, Genetic,
pubmed-meshheading:8327507-Molecular Sequence Data,
pubmed-meshheading:8327507-RNA, Transfer,
pubmed-meshheading:8327507-Repetitive Sequences, Nucleic Acid,
pubmed-meshheading:8327507-Retroviridae,
pubmed-meshheading:8327507-Sequence Homology, Nucleic Acid
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pubmed:year |
1993
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pubmed:articleTitle |
Several short interspersed repetitive elements (SINEs) in distant species may have originated from a common ancestral retrovirus: characterization of a squid SINE and a possible mechanism for generation of tRNA-derived retroposons.
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pubmed:affiliation |
Institute of Biological Sciences, University of Tsukuba, Ibaraki, Japan.
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pubmed:publicationType |
Journal Article
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