Linked Life Data

8326460

Source:http://linkedlifedata.com/resource/pubmed/id/8326460

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-8-11
pubmed:abstractText
The cellular distribution of heart-type fatty acid-binding protein (H-FABP) immunoreactivity was examined in normal human tissues using a polyclonal antibody against human H-FABP. Immunoreactivity was detected in cardiomyocytes of both ventricles and atria as well as in all striated muscles investigated. In addition, staining was frequently observed in parietal cells of the stomach, renal epithelial cells, acinar and ductal cells of the breast, ductal cells of the salivary gland, corpus luteum, and Leydig cells of the testis. Adipocytes and vascular endothelial cells were positive but other tissues and cells examined were negative. Old infarcts of the heart replaced by fibrous connective tissues were not labelled. Necrotic cardiomyocytes and morphologically normal cardiomyocytes in acute ischaemic lesions 1 h after onset showed reduced or no H-FABP immunoreactivity. Thus, decreased immunoreactivity for H-FABP may be a good histological marker of damaged cardiomyocytes.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
May
pubmed:issn
0022-3417
pubmed:author
pubmed:issnType
Print
pubmed:volume
170
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
59-65
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Immunohistochemical distribution of heart-type fatty acid-binding protein immunoreactivity in normal human tissues and in acute myocardial infarct.
pubmed:affiliation
Department of Pathology, Fukushima Medical College, Japan.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't