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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
1
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pubmed:dateCreated |
1993-8-12
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pubmed:abstractText |
We have found that an important Th2 cytokine, IL-10, is produced by tissues from patients acutely infected with Leishmania donovani. In all individuals tested, IL-10 mRNA production was increased in lymph nodes taken during acute disease over that observed in postacute samples. In contrast, both pre- and posttreatment lymph nodes had readily detected mRNA for IFN-gamma and IL-2. A down-regulating effect of IL-10 on leishmania-induced proliferative responses was demonstrated when Hu rIL-10 was added to cultures of PBMC from clinically cured individuals. PBMC from individuals with acute visceral leishmaniasis responded to stimulation with leishmania lysate by producing IL-10 mRNA. Simultaneously cultured PBMC collected from the same patients after successful chemotherapy produced no detectable IL-10 mRNA after leishmania antigen stimulation. Neutralizing anti-IL-10 mAb added to PBMC from patients with acute visceral leishmaniasis markedly increased the proliferative response to leishmania lysate. Finally, we observed mRNA for IL-10 and IFN-gamma concurrently in a lesion from a patient with post-kala-azar dermal leishmaniasis (PKDL). These results indicate the production of IL-10 during L. donovani infection, and suggest a role for this cytokine in the regulation of immune responsiveness during visceral leishmaniasis.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1354651,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1357029,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-14420757,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1531351,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1636092,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1655948,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1703785,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1730874,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1730915,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1744584,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1827484,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1847510,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1898663,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1908085,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1925582,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-1940799,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-2145107,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-2161559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-2419430,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-2440339,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-2521244,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-2531194,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-2960769,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-3100620,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-3104456,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-3131431,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-3144002,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-3728795,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-3935667,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-3946739,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-6287683,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-6329026,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-6415111,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-6725947,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8326000-8419468
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
AIM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Jul
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pubmed:issn |
0021-9738
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:volume |
92
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
324-9
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8326000-Animals,
pubmed-meshheading:8326000-Cytokines,
pubmed-meshheading:8326000-Gene Expression,
pubmed-meshheading:8326000-Humans,
pubmed-meshheading:8326000-Interleukin-10,
pubmed-meshheading:8326000-Leishmania donovani,
pubmed-meshheading:8326000-Leishmaniasis, Visceral,
pubmed-meshheading:8326000-Lymph Nodes,
pubmed-meshheading:8326000-Lymphocyte Activation,
pubmed-meshheading:8326000-RNA, Messenger
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pubmed:year |
1993
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pubmed:articleTitle |
Interleukin 10 production correlates with pathology in human Leishmania donovani infections.
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pubmed:affiliation |
University of Juba, College of Medicine, Khartoum, Sudan.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, P.H.S.,
Research Support, Non-U.S. Gov't
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