Linked Life Data

8325955

Source:http://linkedlifedata.com/resource/pubmed/id/8325955

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1993-8-6
pubmed:abstractText
Sex-steroid based male contraceptive regimes induce azoospermia in only 40-70% of Caucasian men. The reason(s) why the remainder maintains a low level of spermatogenesis (oligozoospermia) despite gonadotrophin suppression is unclear. In order to improve our understanding of this phenomenon, we examined the changes in sperm density and plasma LH, FSH, testosterone (T), oestradiol (E2), and inhibin (IN) in 28 normal men who received 200 mg testosterone enanthate (TE) im weekly during a male contraceptive efficacy trial. Gonadotrophins were measured by an ultrasensitive time-resolved immunofluorometric assay (DELFIA) with a sensitivity of 0.04 U/L, to determine the adequacy of suppression. Seventeen of the 28 men achieved azoospermia; the other 11 remained oligozoospermic (sperm density 3.3-4.7 x 10(6)/mL) after 6 months of TE exposure. Azoospermic subjects displayed a more rapid decline in sperm density, a significant difference being apparent by 5 weeks after starting TE. During TE treatment, both LH and FSH were consistently suppressed to below the limits of detection, whereas there was a 2.5-fold rise in T and E2 with a similar decrease in IN. There were no consistent differences in any of these hormone concentrations between the azoospermic and oligozoospermic groups. Recovery of sperm density to baseline levels or above 20 x 10(6)/mL was significantly slower in the azoospermic group. During the recovery phase, the azoospermic men exhibited significantly higher LH and FSH levels compared to baseline and to the oligozoospermic subjects even though no differences in circulating T, E2, or IN were observed. We conclude that incomplete gonadotrophin suppression or differences in sex steroid or inhibin levels are unlikely to be responsible for the maintenance of minor degrees of spermatogenesis in some men during TE administration. The rebound rise in gonadotrophins in azoospermic but not oligozoospermic responders during recovery may reflect a more profound degree of spermatogenic suppression in the former group.
pubmed:keyword
http://linkedlifedata.com/resource/pubmed/keyword/Androgens, http://linkedlifedata.com/resource/pubmed/keyword/Biology, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Research, http://linkedlifedata.com/resource/pubmed/keyword/Clinical Trials, http://linkedlifedata.com/resource/pubmed/keyword/Comparative Studies, http://linkedlifedata.com/resource/pubmed/keyword/Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, http://linkedlifedata.com/resource/pubmed/keyword/Contraceptive Agents, Male, http://linkedlifedata.com/resource/pubmed/keyword/Developed Countries, http://linkedlifedata.com/resource/pubmed/keyword/ESTRADIOL, http://linkedlifedata.com/resource/pubmed/keyword/Endocrine System, http://linkedlifedata.com/resource/pubmed/keyword/Estrogens, http://linkedlifedata.com/resource/pubmed/keyword/Europe, http://linkedlifedata.com/resource/pubmed/keyword/Family Planning, http://linkedlifedata.com/resource/pubmed/keyword/Follicle Stimulating Hormone, http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins, http://linkedlifedata.com/resource/pubmed/keyword/Gonadotropins, Pituitary--changes, http://linkedlifedata.com/resource/pubmed/keyword/Hormones, http://linkedlifedata.com/resource/pubmed/keyword/Luteinizing Hormone, http://linkedlifedata.com/resource/pubmed/keyword/Male Contraception, http://linkedlifedata.com/resource/pubmed/keyword/Northern Europe, http://linkedlifedata.com/resource/pubmed/keyword/Physiology, http://linkedlifedata.com/resource/pubmed/keyword/Research Report, http://linkedlifedata.com/resource/pubmed/keyword/Reversibility, http://linkedlifedata.com/resource/pubmed/keyword/Spermatogenesis Blocking Agents, http://linkedlifedata.com/resource/pubmed/keyword/Studies, http://linkedlifedata.com/resource/pubmed/keyword/Testosterone, http://linkedlifedata.com/resource/pubmed/keyword/United Kingdom
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
AIM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0021-972X
pubmed:author
pubmed:issnType
Print
pubmed:volume
77
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
290-3
pubmed:dateRevised
2006-11-15
pubmed:otherAbstract
PIP: In the UK, 28 healthy, fertile, white 23-40 year old men received an intramuscular injection of 200 mg testosterone enanthate (TE) during a male contraceptive efficacy trial. Only 17 men achieved azoospermia. Researchers used ultrasensitive immunofluorometric assay to measure gonadotropins and took venous blood samples right before the next TE injection to measure circulating steroid and inhibit (IN) levels. They wanted to determine whether gonadotropin suppression or changes in circulating steroid and IN levels during TE administration maintain some level of spermatogenesis in the 11 oligozoospermic men. At 5 weeks after beginning TE administration, azoospermic men experienced a more rapid fall in sperm density than oligozoospermic men (18.7 x 1 million/mL vs. 48.4 x 1 million/mL; p .05). In both groups, luteinizing hormone (LH) and follicle stimulating hormone (FSH) levels were always lower than the assay detection limit during TE administration. On the other hand, after TE administration, testosterone (T) and estradiol (E2) levels increased 2.5 times while IN levels fell 2.5 times. Azoospermic men recovered sperm density at or above 20 x 1 million/mL at a slower rate than did oligozoospermic men (p .01). They had significantly higher LH and FSH levels during the recovery phase compared to baseline levels and to those of oligozoospermic men (p .05). Yet, circulating levels of T, E2, or IN were essentially the same in both groups. These results suggest that neither incomplete suppression if pituitary gonadotropins nor differences in sex steroid or IN levels would likely account for the differences in the degree of spermatogenic suppression in the 2 groups of men receiving exogenous TE administration. The faster rise in gonadotropins in azoospermic men during recovery may intimate that they experience a more profound degree of spermatogenic suppression.
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Comparison between testosterone enanthate-induced azoospermia and oligozoospermia in a male contraceptive study. I: Plasma luteinizing hormone, follicle stimulating hormone, testosterone, estradiol, and inhibin concentrations.
pubmed:affiliation
Department of Clinical Biochemistry, Royal Infirmary Edinburgh, Scotland.
pubmed:publicationType
Journal Article, Comparative Study, Research Support, Non-U.S. Gov't