Linked Life Data

8325713

Source:http://linkedlifedata.com/resource/pubmed/id/8325713

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
5
pubmed:dateCreated
1993-8-12
pubmed:abstractText
It has previously been shown that most of the B16F10 melanoma cells delivered to the mouse liver via the portal vein are rapidly killed in periportal zone 1 of the sinusoids. Few intact viable cells reach pericentral zone 3 of the sinusoids and of these, only a very small proportion leave the liver to colonize the lungs. The hypothesis has been advanced that one non-exclusive, potential mechanism for cancer-cell destruction in the liver is a result of the deformation of cancer cells when they enter vessels of smaller diameter than themselves. Where entry is associated with change in shape from spheroid to cylindrical, a mandatory increase in cancer-cell surface area occurs, which is first apparent and utilizes surface membrane excess (rugosity). If this increase is insufficient, a real increase occurs which, if in excess of approximately 4%, results in lethal surface membrane rupture. This hypothesis predicts that, under these circumstances, cancer-cell resistance to mechanical trauma is favored by small diameter and utilizable surface membrane excess. To test this hypothesis, the traffic of melanoma cells in the liver following portal-vein injection has been observed by confocal microscopy and image reconstruction. In accordance with the hypothesis, non-disrupted cells within the sinusoids have a smaller mean diameter than that of the original inoculum, and show evidence of utilization of surface membrane excess. The results indicate that deformation-associated trauma, suffered by cancer cells on entry and residence in the microvasculature, may well be an important factor contributing to metastatic inefficiency.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jul
pubmed:issn
0020-7136
pubmed:author
pubmed:issnType
Print
pubmed:day
9
pubmed:volume
54
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
880-4
pubmed:dateRevised
2007-7-24
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Cancer-cell traffic in the liver. III Lethal deformation of B16 melanoma cells in liver sinusoids.
pubmed:affiliation
Department of Experimental Pathology, Roswell Park Cancer Institute, Buffalo, NY.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't