Linked Life Data

8325491

Source:http://linkedlifedata.com/resource/pubmed/id/8325491

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1993-8-12
pubmed:abstractText
We show that in polymorphic populations many polygenic traits pleiotropically related to fitness are expected to be under apparent "stabilizing selection" independently of the real selection acting on the population. This occurs, for example, if the genetic system is at a stable polymorphic equilibrium determined by selection and the nonadditive contributions of the loci to the trait value either are absent, or are random and independent of those to fitness. Stabilizing selection is also observed if the polygenic system is at an equilibrium determined by a balance between selection and mutation (or migration) when both additive and nonadditive contributions of the loci to the trait value are random and independent of those to fitness. We also compare different viability models that can maintain genetic variability at many loci with respect to their ability to account for the strong stabilizing selection on an additive trait. Let Vm be the genetic variance supplied by mutation (or migration) each generation, Vg be the genotypic variance maintained in the population, and n be the number of the loci influencing fitness. We demonstrate that in mutation (migration)-selection balance models the strength of apparent stabilizing selection is order Vm/Vg. In the overdominant model and in the symmetric viability model the strength of apparent stabilizing selection is approximately 1/(2n) that of total selection on the whole phenotype. We show that a selection system that involves pairwise additive by additive epistasis in maintaining variability can lead to a lower genetic load and genetic variance in fitness (approximately 1/(2n) times) than an equivalent selection system that involves overdominance. We show that, in the epistatic model, the apparent stabilizing selection on an additive trait can be as strong as the total selection on the whole phenotype.
pubmed:commentsCorrections
http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-1427047, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-1485273, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-17246488, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-2016044, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-2311921, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-2384723, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-2731731, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-2806884, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-3596236, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-3744046, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-3957009, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-4672513, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-604166, http://linkedlifedata.com/resource/pubmed/commentcorrection/8325491-6794031
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Jun
pubmed:issn
0016-6731
pubmed:author
pubmed:issnType
Print
pubmed:volume
134
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
609-25
pubmed:dateRevised
2010-9-10
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Pleiotropic models of polygenic variation, stabilizing selection, and epistasis.
pubmed:affiliation
N.I. Vavilov Institute of General Genetics, Moscow, Russia.
pubmed:publicationType
Journal Article