| pubmed-article:8324751 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8324751 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:8324751 | lifeskim:mentions | umls-concept:C0006118 | lld:lifeskim |
| pubmed-article:8324751 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:8324751 | lifeskim:mentions | umls-concept:C1707455 | lld:lifeskim |
| pubmed-article:8324751 | lifeskim:mentions | umls-concept:C1152247 | lld:lifeskim |
| pubmed-article:8324751 | lifeskim:mentions | umls-concept:C0205117 | lld:lifeskim |
| pubmed-article:8324751 | pubmed:issue | 14 | lld:pubmed |
| pubmed-article:8324751 | pubmed:dateCreated | 1993-8-10 | lld:pubmed |
| pubmed-article:8324751 | pubmed:abstractText | We assayed the activity of the DNA repair protein O6-methylguanine-DNA methyltransferase (MGMT) in 60 human brain tumors to assess the effects of tumorigenesis in brain on DNA repair capability. Activity was not detectable (< 0.5 fmol/10(6) cells, i.e., < 300 molecules/cells) in 27% of the tumors. Measurable MGMT varied by more than 2 orders of magnitude, 0.5-104.1 fmol/10(6) cells. Mean tumor MGMT levels did not differ between the sexes but did vary widely between diagnostic groups. A significant inverse correlation was observed between tumor MGMT activity and patient age. We also assayed MGMT activity in overlying, histologically tumor-free brain resected with 25 tumors. Of these samples, 52% had no detectable MGMT activity, and the remainder had activity comparable to that in tumors ranging from 0.7-21.8 fmol/10(6) cells. MGMT activity in normal brain was also inversely correlated with patient age. For 15 of 25 (60%) paired samples, tumor activity was 2 to > 38-fold greater than that of normal brain; for 4 pairs (16%) tumor activity was 2.5 to > 17-fold lower than that of normal brain; the remaining 6 (24%) had no detectable activity in both tumor and normal tissue. These differences in the magnitudes and distributions of activities for tumor versus normal brain tissue were significant (P = 0.02), demonstrating that tumorigenesis in brain is often accompanied by marked elevation of MGMT. | lld:pubmed |
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| pubmed-article:8324751 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8324751 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8324751 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:8324751 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8324751 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:8324751 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:8324751 | pubmed:author | pubmed-author:SilberJ RJR | lld:pubmed |
| pubmed-article:8324751 | pubmed:author | pubmed-author:BergerM SMS | lld:pubmed |
| pubmed-article:8324751 | pubmed:author | pubmed-author:MuellerB ABA | lld:pubmed |
| pubmed-article:8324751 | pubmed:author | pubmed-author:EwersT GTG | lld:pubmed |
| pubmed-article:8324751 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8324751 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:8324751 | pubmed:volume | 53 | lld:pubmed |
| pubmed-article:8324751 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8324751 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8324751 | pubmed:pagination | 3416-20 | lld:pubmed |
| pubmed-article:8324751 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:8324751 | pubmed:meshHeading | pubmed-meshheading:8324751-... | lld:pubmed |
| pubmed-article:8324751 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8324751 | pubmed:articleTitle | Comparison of O6-methylguanine-DNA methyltransferase activity in brain tumors and adjacent normal brain. | lld:pubmed |
| pubmed-article:8324751 | pubmed:affiliation | Department of Neurological Surgery, University of Washington, Seattle 98195. | lld:pubmed |
| pubmed-article:8324751 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8324751 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:8324751 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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