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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
1
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pubmed:dateCreated |
1993-8-5
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pubmed:abstractText |
The effect of noradrenaline (NA) on mucociliary activity in the rabbit maxillary sinus was investigated in vivo by injecting it at increasing dosages (10(-11) to 10(-4) mol/kg) into the maxillary artery, the mucociliary response being recorded photoelectrically. NA increased mucociliary activity at a dosage of 10(-5) mol/kg, the maximal increase being 16.1 +/- 2.6%. The NA-induced stimulation of mucociliary activity had a latency of 20 s, and the activity returned to base-line level within 3 min. Pretreatment with the alpha-antagonist phentolamine (0.2 and 1.0 mg/kg) or the cholinergic antagonist atropine (1 mg/kg) did not alter mucociliary response to NA. Blockade with the beta-antagonist propranolol did not significantly reduce the maximal response to NA, which was 16.1 +/- 2.6% before and 11.1 +/- 3.0% after pretreatment with propranolol (n = 7; p = 0.2). In contrast, pretreatment with the prostaglandin-synthesis inhibitor indomethacin reduced the response from 12.9 +/- 2.9% to 6.3 +/- 1.3% (n = 6; p < 0.05), suggesting that at high dosages NA stimulates mucociliary activity via the cyclo-oxygenase pathway.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Atropine,
http://linkedlifedata.com/resource/pubmed/chemical/Indomethacin,
http://linkedlifedata.com/resource/pubmed/chemical/Norepinephrine,
http://linkedlifedata.com/resource/pubmed/chemical/Phentolamine,
http://linkedlifedata.com/resource/pubmed/chemical/Propranolol
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pubmed:status |
MEDLINE
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pubmed:month |
Mar
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pubmed:issn |
0300-0729
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
31
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
17-21
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pubmed:dateRevised |
2006-11-15
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pubmed:meshHeading |
pubmed-meshheading:8321977-Animals,
pubmed-meshheading:8321977-Atropine,
pubmed-meshheading:8321977-Dose-Response Relationship, Drug,
pubmed-meshheading:8321977-Female,
pubmed-meshheading:8321977-Indomethacin,
pubmed-meshheading:8321977-Injections, Intra-Arterial,
pubmed-meshheading:8321977-Male,
pubmed-meshheading:8321977-Maxillary Sinus,
pubmed-meshheading:8321977-Mucociliary Clearance,
pubmed-meshheading:8321977-Norepinephrine,
pubmed-meshheading:8321977-Phentolamine,
pubmed-meshheading:8321977-Propranolol,
pubmed-meshheading:8321977-Rabbits
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pubmed:year |
1993
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pubmed:articleTitle |
The effect of noradrenaline on mucociliary activity in the rabbit maxillary sinus.
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pubmed:affiliation |
Department of Otorhinolaryngology, University Hospital, Lund, Sweden.
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pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
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