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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-8-5
|
| pubmed:abstractText |
The serodiagnostic tests, beta-glucan, mannan, candida antigen by Cand-Tec, and D-arabinitol were evaluated in 10 patients with candidemia, 14 patients with suspected fungemia, and 10 healthy persons. By blood culture or lysis centrifugation, C. albicans was isolated from 5 patients, C. parapsilosis from 4, and C. tropicalis from 1 patient; no organisms were isolated from the 14 patients with suspected fungemia or the 10 healthy subjects. Beta-glucan was measured by the difference between two chromogenic limulus tests (Endotoxin test-D and Endospecy), which was more than 60 pg/ml in 7 of 9 (78%) candidemic patients and 1 of 12 (8%) patients with suspected fungemia. Mannan was positive in 6 of 10 (60%) candidemic patients and 1 of 13 (8%) patients with suspected fungemia. Both antigens were very sensitive and highly specific for candidemia. However, the Cand-Tec assay was less specific, because titers of more than 4 were observed in 5 of 14 (34%) patients with suspected fungemia. D-Arabinitol was the least sensitive, because a D-arabinitol/creatinine ratio greater than 2.0 mumol/mg was observed in only 2 of 7 (29%) candidemic patients. The titers of serodiagnostic tests decreased after successful treatment with an anti-fungal agent. Our results show that the combined use of the assays in necessary for accurate serological diagnosis of candidemia.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Antigens, Fungal,
http://linkedlifedata.com/resource/pubmed/chemical/Glucans,
http://linkedlifedata.com/resource/pubmed/chemical/Mannans,
http://linkedlifedata.com/resource/pubmed/chemical/Sugar Alcohols,
http://linkedlifedata.com/resource/pubmed/chemical/arabitol
|
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0385-5600
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
37
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
207-12
|
| pubmed:dateRevised |
2007-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8321149-Adolescent,
pubmed-meshheading:8321149-Adult,
pubmed-meshheading:8321149-Aged,
pubmed-meshheading:8321149-Aged, 80 and over,
pubmed-meshheading:8321149-Agglutination Tests,
pubmed-meshheading:8321149-Antigens, Fungal,
pubmed-meshheading:8321149-Candida,
pubmed-meshheading:8321149-Candidiasis,
pubmed-meshheading:8321149-Evaluation Studies as Topic,
pubmed-meshheading:8321149-Female,
pubmed-meshheading:8321149-Fungemia,
pubmed-meshheading:8321149-Glucans,
pubmed-meshheading:8321149-Humans,
pubmed-meshheading:8321149-Male,
pubmed-meshheading:8321149-Mannans,
pubmed-meshheading:8321149-Middle Aged,
pubmed-meshheading:8321149-Sensitivity and Specificity,
pubmed-meshheading:8321149-Serologic Tests,
pubmed-meshheading:8321149-Sugar Alcohols
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
An evaluation of serodiagnostic tests in patients with candidemia: beta-glucan, mannan, candida antigen by Cand-Tec and D-arabinitol.
|
| pubmed:affiliation |
Second Department of Internal Medicine, Nagasaki University School of Medicine, Japan.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|