Linked Life Data

8321010

Source:http://linkedlifedata.com/resource/pubmed/id/8321010

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1993-7-30
pubmed:abstractText
We describe a simple, scaled-down instrument which enables accurate, reproducible stereotaxic placements into specific sites in the brain of the newborn rat. The instrument is specially designed for the administration of long-term hypothermia, yet permits the use of alternative methods of anesthesia. The design of the head-stabilizing mechanism allows head positioning to be finely adjusted to achieve precise horizontal and vertical zero planes. This adaptability also allows the device to accommodate a large range of animal sizes and levels of maturity. Furthermore, the apparatus can be fitted onto a conventional adult stereotaxic frame or used by itself in combination with a free-standing manipulator. As a model preparation, we describe a procedure for stereotaxic surgery in the post-natal day (P1) rat. The versatility of the instrument has permitted successful stereotaxic surgery in adolescent as well as neonatal rats, newborn and adult mice, and newborn hamsters.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:status
MEDLINE
pubmed:month
Apr
pubmed:issn
0165-0270
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
105-14
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
A hypothermic miniaturized stereotaxic instrument for surgery in newborn rats.
pubmed:affiliation
Department of Brain and Cognitive Sciences, Massachusetts Institute of Technology, Cambridge 02139.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't