Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1993-8-5
|
| pubmed:abstractText |
Hyperhomocysteinemia has been shown to constitute an independent risk factor for premature occlusive arterial disease (N Engl J Med 324:1149), a frequent complication in chronic uremic patients in whom homocysteine (Hcy) accumulation has been reported to occur. We prospectively determined fasting plasma level of total, protein-bound Hcy in 118 adult chronic uremic patients, either dialyzed or not. In 79 non-dialyzed patients (47 male) with various degrees of chronic renal failure (RF) assessed by creatinine clearance (CCr), none receiving folate, B6 or B12 vitamin supplementation, mean (+/- 1 SD) plasma Hcy level was 16.2 +/- 8.1 mumol/liter in 28 patients with mild RF (CCr 30 to 75 ml/min), 23.3 +/- 14.7 in 29 patients with moderate RF (CCr 10 to 29.9), and 29.5 +/- 14.4 in 22 patients with advanced RF (CCr < 10), a significant difference (P < 0.01 for all groups) compared to 45 healthy controls (8.2 +/- 2.2 mumol/liter). Linear regression analysis showed a significant correlation between plasma creatinine and Hcy concentrations (r = 0.49, P < 0.0001). Hcy was significantly higher in 20 patients (16 males) who had past histories of occlusive arterial disease than in the 59 (31 males) who did not (30.9 +/- 19.1 vs. 19.6 +/- 9.7 mumol/liter, P < 0.001) and all of the former had Hcy level > 14.1 mumol/liter (the upper limit in healthy controls) versus 35 of 59 in the latter.(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Jun
|
| pubmed:issn |
0098-6577
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
S72-7
|
| pubmed:dateRevised |
2004-11-17
|
| pubmed:meshHeading |
pubmed-meshheading:8320950-Adolescent,
pubmed-meshheading:8320950-Adult,
pubmed-meshheading:8320950-Aged,
pubmed-meshheading:8320950-Aged, 80 and over,
pubmed-meshheading:8320950-Arterial Occlusive Diseases,
pubmed-meshheading:8320950-Arteriosclerosis,
pubmed-meshheading:8320950-Chronic Disease,
pubmed-meshheading:8320950-Female,
pubmed-meshheading:8320950-Homocysteine,
pubmed-meshheading:8320950-Humans,
pubmed-meshheading:8320950-Male,
pubmed-meshheading:8320950-Middle Aged,
pubmed-meshheading:8320950-Risk Factors,
pubmed-meshheading:8320950-Uremia
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Hyperhomocysteinemia, a risk factor for atherosclerosis in chronic uremic patients.
|
| pubmed:affiliation |
Department of Nephrology, Necker Hospital, Paris, France.
|
| pubmed:publicationType |
Journal Article
|