|
rdf:type |
|
|
lifeskim:mentions |
|
|
pubmed:dateCreated |
1993-7-27
|
|
pubmed:abstractText |
Tamoxifen and 4-hydroxytamoxifen protect isolated human low-density lipoproteins (LDLs) against copper-ion-dependent lipid peroxidation: 4-hydroxytamoxifen is more protective than tamoxifen or 17 beta-oestradiol. 4-Hydroxytamoxifen and 17 beta-oestradiol also prevent the increase in the electrophoretic mobility of LDL caused by exposure to copper ions, presumably by protection of the apoprotein B of LDL against oxidative modification. Our observations may help to account for the cardioprotective benefits reported to be associated with tamoxifen therapy and prophylaxis in breast cancer.
|
|
pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1230004,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1311141,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1322240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1328822,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1329721,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1346404,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1349935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1373360,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1377370,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1392827,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1398217,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1423428,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1524921,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1547281,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1554887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1579062,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1582240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1622642,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1672017,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1884432,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1912833,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-1952472,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-2095926,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-2253763,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-2328927,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-2335223,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-2648148,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-2722022,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-3942559,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-7381323,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8317992-98070
|
|
pubmed:language |
eng
|
|
pubmed:journal |
|
|
pubmed:citationSubset |
IM
|
|
pubmed:chemical |
|
|
pubmed:status |
MEDLINE
|
|
pubmed:month |
Jun
|
|
pubmed:issn |
0264-6021
|
|
pubmed:author |
|
|
pubmed:issnType |
Print
|
|
pubmed:day |
15
|
|
pubmed:volume |
292 ( Pt 3)
|
|
pubmed:owner |
NLM
|
|
pubmed:authorsComplete |
Y
|
|
pubmed:pagination |
635-8
|
|
pubmed:dateRevised |
2009-11-18
|
|
pubmed:meshHeading |
pubmed-meshheading:8317992-Copper,
pubmed-meshheading:8317992-Electrophoresis, Agar Gel,
pubmed-meshheading:8317992-Estradiol,
pubmed-meshheading:8317992-Heart,
pubmed-meshheading:8317992-Humans,
pubmed-meshheading:8317992-Kinetics,
pubmed-meshheading:8317992-Lipid Peroxidation,
pubmed-meshheading:8317992-Lipoproteins, LDL,
pubmed-meshheading:8317992-Molecular Weight,
pubmed-meshheading:8317992-Oxidation-Reduction,
pubmed-meshheading:8317992-Tamoxifen
|
|
pubmed:year |
1993
|
|
pubmed:articleTitle |
Protective actions of tamoxifen and 4-hydroxytamoxifen against oxidative damage to human low-density lipoproteins: a mechanism accounting for the cardioprotective action of tamoxifen?
|
|
pubmed:affiliation |
Pharmacology Group, King's College, University of London, U.K.
|
|
pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|
