Linked Life Data

8317887

Source:http://linkedlifedata.com/resource/pubmed/id/8317887

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1993-7-28
pubmed:abstractText
The effect of the phenothiazine derivative fluphenazine has been studied in the human leukemic T-cell line H33-HJ JA1, which is an Interleukin-2 (IL-2) producing cell line derived from Jurkat cells. This cell line shows a highly proliferative activity in response to the autocrine produced IL-2. The phenothiazine fluphenazine (1-10 microM) inhibited this proliferation in a dose-dependent manner, as evidenced by the incorporation of (3H)-Thymidine. In analogy, growth inhibition by fluphenazine has been investigated in the human myeloblastic HL-60 cell line. The spontaneous growth of this cell line was also inhibited by fluphenazine at pharmacologically relevant micromolar concentrations. These results suggest that the use of phenothiazines might be helpful in antileukemic regimens.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0250-7005
pubmed:author
pubmed:issnType
Print
pubmed:volume
13
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
599-602
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:articleTitle
Growth inhibition of human leukemic cell lines by the phenothiazine derivative fluphenazine.
pubmed:affiliation
Department of Internal Medicine III, Klinikum Grosshadern, University of Munich, Germany.
pubmed:publicationType
Journal Article