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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1993-7-29
|
| pubmed:abstractText |
We measured changes in basal release of nitric oxide (NO) and its effect on polymorphonuclear neutrophil (PMN) adherence to endothelial cells (EC) in a feline model of myocardial ischemia and reperfusion (MI/R). Significant reductions in basal NO release occurred 10 minutes following reperfusion, whereas increases in PMN adherence occurred at 20 minutes post-reperfusion. Addition of hSOD blocked the post-reperfusion adherence of PMNs to the endothelium. These results indicate that decreased basal release of NO, following MI/R precedes enhanced PMN adherence to the coronary endothelium, which may lead to PMN-induced myocardial injury.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0379-0363
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
41
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
127-35
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8317336-Animals,
pubmed-meshheading:8317336-Arginine,
pubmed-meshheading:8317336-Cats,
pubmed-meshheading:8317336-Cell Adhesion,
pubmed-meshheading:8317336-Coronary Vessels,
pubmed-meshheading:8317336-Endothelium, Vascular,
pubmed-meshheading:8317336-Myocardial Reperfusion Injury,
pubmed-meshheading:8317336-NG-Nitroarginine Methyl Ester,
pubmed-meshheading:8317336-Neutrophils,
pubmed-meshheading:8317336-Nitric Oxide,
pubmed-meshheading:8317336-Vasoconstrictor Agents
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Endothelial dysfunction and neutrophil adherence as critical events in the development of reperfusion injury.
|
| pubmed:affiliation |
Department of Physiology, Jefferson Medical College, Thomas Jefferson University, Philadelphia, PA 19107.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|