Switch to
| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
3
|
| pubmed:dateCreated |
1993-7-23
|
| pubmed:abstractText |
10-16-Week-old female BALB/c mice received low dose total body irradiation (LDTBI) in one fraction immediately before the beginning of treatment with recombinant human interleukin-2 (rIL-2). LDTBI prevented in a dose-dependent manner the weight increase of the spleen, liver and lungs induced by fluid extravasation provoked by rIL-2 injections. It also limited the increase of the number of mononuclear cells in the spleen induced after in vivo treatment with rIL-2. Immunofluorescence analysis of spleen cells revealed that LDTBI decreased the relative sIgM+ cell number in spleen, while the relative numbers of Lyt-1+, Thy-1+ and L3T4+ cells were increased, indicating that a T and/or NK population, radioresistant to LDTBI, could still proliferate under rIL-2 stimulation in vivo. Such lymphocytes were capable of in vitro lysis of YAC cells in a 4-hour 51Cr release assay, as well as lymphokine-activated killer (LAK) cells obtained in mice treated with rIL-2 alone. Thus, LDTBI given prior to rIL-2, yet preserving the cytotoxic capacity of the LAK cells activated by rIL-2, could prevent the vascular leak syndrome toxicity induced by rIL-2 injection.
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
Mar
|
| pubmed:issn |
0167-8140
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
26
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
219-25
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8316651-Animals,
pubmed-meshheading:8316651-B-Lymphocytes,
pubmed-meshheading:8316651-Capillary Permeability,
pubmed-meshheading:8316651-Cell Count,
pubmed-meshheading:8316651-Cytotoxicity, Immunologic,
pubmed-meshheading:8316651-Dose-Response Relationship, Immunologic,
pubmed-meshheading:8316651-Dose-Response Relationship, Radiation,
pubmed-meshheading:8316651-Female,
pubmed-meshheading:8316651-Humans,
pubmed-meshheading:8316651-Interleukin-2,
pubmed-meshheading:8316651-Killer Cells, Lymphokine-Activated,
pubmed-meshheading:8316651-Killer Cells, Natural,
pubmed-meshheading:8316651-Liver,
pubmed-meshheading:8316651-Lung,
pubmed-meshheading:8316651-Mice,
pubmed-meshheading:8316651-Mice, Inbred BALB C,
pubmed-meshheading:8316651-Organ Size,
pubmed-meshheading:8316651-Radiation Dosage,
pubmed-meshheading:8316651-Spleen,
pubmed-meshheading:8316651-T-Lymphocytes,
pubmed-meshheading:8316651-Vascular Diseases,
pubmed-meshheading:8316651-Whole-Body Irradiation
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Effects of low dose total body irradiation (LDTBI) and recombinant human interleukin-2 in mice.
|
| pubmed:affiliation |
Département de Radiothérapie, INSERM U.255, Institut Curie, Paris, France.
|
| pubmed:publicationType |
Journal Article,
Research Support, Non-U.S. Gov't
|