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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:dateCreated |
1993-7-27
|
| pubmed:abstractText |
Ivermectin has been shown to increase chloride conductances of invertebrate cells. On the muscle cells of the parasitic nematode Ascaris, ivermectin acts as both a GABA receptor antagonist and a chloride channel opener. In this study, ion-sensitive microelectrodes were used to investigate the effect of ivermectin on intracellular Cl- concentration of the somatic muscle bag cells of Ascaris suum. Incubation of muscle cells with ivermectin (10 microM in 1% dimethyl sulphoxide vehicle for 60 min) increased intracellular Cl- by 2.9 mM or 15% compared to controls (P < 0.01, n = 6).
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:month |
May
|
| pubmed:issn |
0031-1820
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
106 ( Pt 4)
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
421-7
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8316438-Animals,
pubmed-meshheading:8316438-Ascaris suum,
pubmed-meshheading:8316438-Chlorides,
pubmed-meshheading:8316438-Dimethyl Sulfoxide,
pubmed-meshheading:8316438-Ions,
pubmed-meshheading:8316438-Ivermectin,
pubmed-meshheading:8316438-Membrane Potentials,
pubmed-meshheading:8316438-Microelectrodes,
pubmed-meshheading:8316438-Muscles,
pubmed-meshheading:8316438-Sensitivity and Specificity,
pubmed-meshheading:8316438-Water-Electrolyte Balance
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
An ion-sensitive microelectrode study on the effect of a high concentration of ivermectin on chloride balance in the somatic muscle bag cells of Ascaris suum.
|
| pubmed:affiliation |
Department of Physiology and Pharmacology, University of Southampton, UK.
|
| pubmed:publicationType |
Journal Article,
In Vitro
|