| pubmed-article:8314446 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8314446 | lifeskim:mentions | umls-concept:C0011849 | lld:lifeskim |
| pubmed-article:8314446 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:8314446 | lifeskim:mentions | umls-concept:C0221102 | lld:lifeskim |
| pubmed-article:8314446 | lifeskim:mentions | umls-concept:C0752224 | lld:lifeskim |
| pubmed-article:8314446 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:8314446 | pubmed:dateCreated | 1993-7-23 | lld:pubmed |
| pubmed-article:8314446 | pubmed:abstractText | Kidney haemodynamics appear to change after the early phases of diabetic nephropathy: increases in glomerular filtration rate and in renal plasma flow have been widely reported, while kidney size is increased. As the renal kallikrein-kinin system has been demonstrated to regulate kidney blood circulation, we have evaluated the excretion of urinary kallikrein in 87 Type 1 (insulin-dependent) diabetic patients with and without hyperfiltration. Urinary kallikrein excretion was measured in 24-h urine collections. The esterolytic activity was determined by fluorimetric assay. The excretion of urinary kallikreins was significantly higher in hyperfiltering patients (472 +/- 125 esterase units/24 h) than in normofiltering (168 +/- 77 esterase units/24 h) and control subjects (151 +/- 39 esterase units/24 h), p < 0.001. Furthermore, we observed a positive correlation between urinary kallikrein excretion and glomerular filtration rate (r = 0.785). These data suggest that variations of kallikrein and kinin concentrations may play a role in the alteration of renal haemodynamics in Type 1 diabetes. It is possible that the kinin-kallikrein system, the renin-angiotensin system and the prostaglandins may interact to determine the haemodynamic alterations which are present in the diabetic disease. | lld:pubmed |
| pubmed-article:8314446 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8314446 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8314446 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8314446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8314446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8314446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8314446 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8314446 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8314446 | pubmed:month | May | lld:pubmed |
| pubmed-article:8314446 | pubmed:issn | 0012-186X | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:GrecoA VAV | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:GhirlandaGG | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:MagnaniPP | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:PorcelliGG | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:D'ErricoGG | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:MarraGG | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:MantaSS | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:CotroneoPP | lld:pubmed |
| pubmed-article:8314446 | pubmed:author | pubmed-author:TilliPP | lld:pubmed |
| pubmed-article:8314446 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8314446 | pubmed:volume | 36 | lld:pubmed |
| pubmed-article:8314446 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8314446 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8314446 | pubmed:pagination | 423-7 | lld:pubmed |
| pubmed-article:8314446 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:8314446 | pubmed:meshHeading | pubmed-meshheading:8314446-... | lld:pubmed |
| pubmed-article:8314446 | pubmed:meshHeading | pubmed-meshheading:8314446-... | lld:pubmed |
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| pubmed-article:8314446 | pubmed:meshHeading | pubmed-meshheading:8314446-... | lld:pubmed |
| pubmed-article:8314446 | pubmed:meshHeading | pubmed-meshheading:8314446-... | lld:pubmed |
| pubmed-article:8314446 | pubmed:year | 1993 | lld:pubmed |
| pubmed-article:8314446 | pubmed:articleTitle | Urinary kallikrein excretion in type 1 (insulin-dependent) diabetes mellitus. | lld:pubmed |
| pubmed-article:8314446 | pubmed:affiliation | Istituto Clinica Medica, Rome, Italy. | lld:pubmed |
| pubmed-article:8314446 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8314446 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
