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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
3
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pubmed:dateCreated |
1993-7-29
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pubmed:abstractText |
With the introduction of immunoscintigraphy (IS) with 99mTc-labelled anti-CEA monoclonal antibodies (MoAb), a clinical relevant method in nuclear medicine can be expected in the diagnosis and follow up of colorectal cancers. We performed IS (whole body, planar and SPECT) with a 99mTc-labelled intact anti-CEA MoAb (BW 431/26) in 18 patients with primary colorectal carcinoma, metastases or suspicious recurrences from colorectal carcinoma. The results of anti-CEA IS, serum CEA and Ca 19-9 levels were evaluated. Immunoscintigraphy yielded an overall sensitivity of 70.0%, 37.5% for primary tumors, 75.0% for recurrences and 100% for distant metastases. Serum CEA levels were elevated in 10 out of 18 patients (sensitivity 55.5%) and Ca 19-9 were elevated in eight out of 18 patients (sensitivity 44.4%). In the group of patients with metastases, CEA had a sensitivity of 100% and Ca 19-9, of 83.3%. From this prospective study, we can conclude that IS with 99mTC-BW 431/26 is a reliable tool in the post-operative follow-up study of patients with colorectal carcinoma, namely in the detection of distant metastases.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Jun
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pubmed:issn |
0748-7983
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
19
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
294-9
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pubmed:dateRevised |
2007-7-2
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pubmed:meshHeading |
pubmed-meshheading:8314389-Aged,
pubmed-meshheading:8314389-Aged, 80 and over,
pubmed-meshheading:8314389-Antigens, Tumor-Associated, Carbohydrate,
pubmed-meshheading:8314389-Carcinoembryonic Antigen,
pubmed-meshheading:8314389-Colorectal Neoplasms,
pubmed-meshheading:8314389-Female,
pubmed-meshheading:8314389-Humans,
pubmed-meshheading:8314389-Male,
pubmed-meshheading:8314389-Middle Aged,
pubmed-meshheading:8314389-Prospective Studies,
pubmed-meshheading:8314389-Radioimmunodetection,
pubmed-meshheading:8314389-Sensitivity and Specificity,
pubmed-meshheading:8314389-Technetium
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pubmed:year |
1993
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pubmed:articleTitle |
Immunoscintigraphy with 99mTc-labelled anti-CEA monoclonal antibody in colorectal carcinoma.
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pubmed:affiliation |
Nuclear Medicine Department, Portuguese Institute of Oncology, Lisbon.
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pubmed:publicationType |
Journal Article,
Research Support, U.S. Gov't, Non-P.H.S.
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