Linked Life Data

8311512

Source:http://linkedlifedata.com/resource/pubmed/id/8311512

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-3-17
pubmed:abstractText
Polybrominated biphenyls (PBBs) and perchlorinated terphenyls (PCTs) are industrial chemicals that are long-lasting environmental contaminants. Although in vivo effects of PBBs on reproduction are documented, no information is available on the effects of these chemicals on sperm-egg interactions or fertilization. The present study was undertaken to determine the toxic potential of PBBs and PCTs on in vitro fertilization (IVF) in the mouse. 2-Bromobiphenyl, 4-bromobiphenyl, o-terphenyl, m-terphenyl, and p-terphenyl were added to the IVF medium at various concentrations. Oocytes collected from superovulated B6D2F1 mice were maintained in a medium containing the chemicals. Capacitated sperm were then added and the dishes cultured in a humidified atmosphere at 37 degrees C in 5% CO2 + 95% air. Oocytes were assessed for fertilization 20-24 h after insemination. polybrominated biphenyls and PCTs reduced the IVF rate at the higher dosages. Furthermore, an increased incidence of abnormal two-cell embryos and degenerative oocytes was observed at the 1 and 10 micrograms/ml concentrations of PBBs and PCTs. These results indicate that PBBs and PCTs adversely effect IVF and increase the incidence of abnormal embryos and oocyte degeneration in the mouse.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Feb
pubmed:issn
0090-4341
pubmed:author
pubmed:issnType
Print
pubmed:volume
26
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
208-11
pubmed:dateRevised
2007-11-15
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
The effects of polybrominated biphenyls and perchlorinated terphenyls on in vitro fertilization in the mouse.
pubmed:affiliation
Endocrine Research Center, Michigan State University, East Lansing 48824.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S., Research Support, Non-U.S. Gov't