Linked Life Data

8309274

Source:http://linkedlifedata.com/resource/pubmed/id/8309274

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1-2
pubmed:dateCreated
1994-3-15
pubmed:abstractText
The effect of aging on the lipid composition and fluidity of rat peritoneal macrophage membranes has been determined using young (3 months), mature (12 months) and aged (24 months) Wistar rats. In the aged animals, total phospholipid decreased significantly (P < 0.05), whereas cholesterol increased (P < 0.01), with an age-dependent increase in the molar ratio of cholesterol/phospholipid. The most marked change in phospholipid content was the significant (P < 0.001) age-dependent increase of phosphatidylserine and cardiolipin and the significant decrease of phosphatidylcholine and phosphatidylinositol. During aging there was a considerable decrease in arachidonic acid and docosapentanoic acid (about 50% in both cases). In contrast, an increase in the levels of oleic, linoleic and docosahexanoic acid was observed. Steady-state fluorescence polarization using 1,6-diphenyl-1,3,5-hexatriene as the probe was used to estimate the lipid structural order parameter of macrophage membranes. There was a highly significant (P < 0.001) age-dependent increase in the lipid structural order parameter, which correlated well with the increased molar ratio of cholesterol/phospholipid in the membranes isolated from aged animals. The data suggests alteration in membrane lipid-protein interactions in aging, and are consistent with the hypothesis of the aging process.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Oct
pubmed:issn
0047-6374
pubmed:author
pubmed:issnType
Print
pubmed:day
1
pubmed:volume
71
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
1-12
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Age-dependent modification of lipid composition and lipid structural order parameter of rat peritoneal macrophage membranes.
pubmed:affiliation
Departamento de Bioquímica, Bromatología y Toxicología, Facultad de Farmacía, Universidad de Sevilla, Spain.
pubmed:publicationType
Journal Article, Research Support, Non-U.S. Gov't