Linked Life Data

8307186

Source:http://linkedlifedata.com/resource/pubmed/id/8307186

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
2
pubmed:dateCreated
1994-3-15
pubmed:abstractText
It has been reported in the literature that alpha 1-adrenoceptor activation in adult rat heart does not cause an increase in Ca2+ current but involves a decrease in I(t). This may explain in part the positive inotropic effect of alpha 1-adrenoceptor activation. In this study, the effect of phenylephrine, an alpha-adrenergic agonist, on L-type Ca2+ channel current was compared in young and neonatal rat myocytes. In the presence of propranolol, phenylephrine increased the Ca2+ current (reversed by prazosin) in neonatal but not in young rat myocytes suggesting that the coupling of the alpha 1-adrenoceptor to Ca2+ channels may switch during development.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-5793
pubmed:author
pubmed:issnType
Print
pubmed:day
31
pubmed:volume
338
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
234-8
pubmed:dateRevised
2008-11-21
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Changes in alpha 1-adrenoceptor coupling to Ca2+ channels during development in rat heart.
pubmed:affiliation
Department of Physiology, University of Alberta, Edmonton, Canada.
pubmed:publicationType
Journal Article, Comparative Study