Linked Life Data

8307128

Source:http://linkedlifedata.com/resource/pubmed/id/8307128

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
1
pubmed:dateCreated
1994-3-16
pubmed:abstractText
The elevation and clearance of extracellular potassium concentration ([K+]e) were studied following graded contusion injury of the rat thoracic spinal cord. Animals were anesthetized, paralyzed, laminectomized at T9-T10, and then artificially ventilated. A 10-g rod was dropped 1.25, 2.5, or 5 cm onto the dorsal thoracic cord with the dura intact. After impact, and incision of the dura-arachnoid and pial membranes, double-barreled, potassium-selective microelectrodes were inserted midway between the midline and lateral edge of the cord. For all three injury levels, the elevation of [K+]e was greatest within the first 1000 microns from the dorsal surface. In 50 g-cm injuries, increasing [K+]e was sometimes observed between 250 and 1000 microns; however such gradients were not typically observed in 25 and 12.5 g-cm injuries. Measured at 3-7 min after injury, the mean peak elevations of [K+]e were significantly different, measuring 13 +/- 2.4, 27 +/- 5.5, and 44 +/- 4.2 mM following 12.5, 25, and 50 g-cm contusions, respectively. The exponential half-times of [K+]e clearance averaged 5.8 +/- 1.0, 9.2 +/- 1.8, and 17 +/- 5.7 min for the same respective injury levels. These results indicate that elevation of [K+]e following traumatic injury to the spinal cord is a graded phenomenon, dependent on the energy of impact. This finding is consistent with a mechanism in which simple mechanical injury of cell membranes is the proximate cause of potassium release.
pubmed:grant
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Jan
pubmed:issn
0014-4886
pubmed:author
pubmed:issnType
Print
pubmed:volume
125
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
93-8
pubmed:dateRevised
2007-11-14
pubmed:meshHeading
pubmed:year
1994
pubmed:articleTitle
Elevation and clearance of extracellular K+ following graded contusion of the rat spinal cord.
pubmed:affiliation
Department of Neurosurgery, New York University Medical Center, New York 10016.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.