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Predicate | Object |
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rdf:type | |
lifeskim:mentions | |
pubmed:issue |
10
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pubmed:dateCreated |
1994-3-11
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pubmed:abstractText |
A complement fixation (CF) test, a micro-immunofluorescence (micro-IF) test and an enzyme immunoassay (EIA) using Re-lipopolysaccharide as antigen were compared in the diagnosis of chlamydial infection in 136 mainly elderly patients hospitalized with community-acquired pneumonia during a Chlamydia pneumoniae epidemic in Finland in 1986-1987. Chlamydial pneumonia was diagnosed in 58 (42.6%) of the 136 pneumonia patients; 44 (75.9%) of them could be shown by micro-IF to be caused by Chlamydia pneumoniae, three by Chlamydia psittaci and four by Chlamydia spp. Only 5 (11.4%) of 44 patients with Chlamydia pneumoniae pneumonia were IgM-positive, indicating that the majority of cases were reinfections. In this population of mainly elderly patients the CF test was insensitive, being positive in only 6 (10.3%) of 58 cases of chlamydial pneumonia. The EIA detected 72.4% of cases and micro-IF 87.9% of cases (including infections with Chlamydia pneumoniae, Chlamydia psittaci and Chlamydia spp.). In the EIA 77% of positive cases were positive in serum samples taken a week apart, whereas the corresponding figure for micro-IF was 50%. In micro-IF the measurement of IgA antibody levels is recommended and IgM-positive sera should be retested after removal of IgG antibody to avoid false-positive findings due to presence of rheumatoid factor. The collection of a third serum sample, for instance one month after onset, is also recommended, since half of the patients showed a diagnostic response in the micro-IF only in the sera taken one month apart.
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pubmed:language |
eng
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pubmed:journal | |
pubmed:citationSubset |
IM
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pubmed:chemical | |
pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
0934-9723
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pubmed:author | |
pubmed:issnType |
Print
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pubmed:volume |
12
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
756-60
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pubmed:dateRevised |
2004-11-17
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pubmed:meshHeading |
pubmed-meshheading:8307044-Adolescent,
pubmed-meshheading:8307044-Adult,
pubmed-meshheading:8307044-Aged,
pubmed-meshheading:8307044-Aged, 80 and over,
pubmed-meshheading:8307044-Antibodies, Bacterial,
pubmed-meshheading:8307044-Chlamydia Infections,
pubmed-meshheading:8307044-Chlamydophila pneumoniae,
pubmed-meshheading:8307044-Complement Fixation Tests,
pubmed-meshheading:8307044-Female,
pubmed-meshheading:8307044-Finland,
pubmed-meshheading:8307044-Fluorescent Antibody Technique,
pubmed-meshheading:8307044-Humans,
pubmed-meshheading:8307044-Immunoenzyme Techniques,
pubmed-meshheading:8307044-Male,
pubmed-meshheading:8307044-Middle Aged,
pubmed-meshheading:8307044-Pneumonia,
pubmed-meshheading:8307044-Serologic Tests
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pubmed:year |
1993
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pubmed:articleTitle |
Evaluation of serological methods in the diagnosis of Chlamydia pneumoniae pneumonia during an epidemic in Finland.
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pubmed:affiliation |
Department of Virology, University of Helsinki, Finland.
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pubmed:publicationType |
Journal Article
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