| pubmed-article:8304483 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8304483 | lifeskim:mentions | umls-concept:C0034721 | lld:lifeskim |
| pubmed-article:8304483 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:8304483 | lifeskim:mentions | umls-concept:C0021753 | lld:lifeskim |
| pubmed-article:8304483 | lifeskim:mentions | umls-concept:C0227651 | lld:lifeskim |
| pubmed-article:8304483 | lifeskim:mentions | umls-concept:C0033551 | lld:lifeskim |
| pubmed-article:8304483 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:8304483 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:8304483 | pubmed:issue | 1 Pt 2 | lld:pubmed |
| pubmed-article:8304483 | pubmed:dateCreated | 1994-3-9 | lld:pubmed |
| pubmed-article:8304483 | pubmed:abstractText | In primary cultures of rat mesangial cells from passage 3 to 6, interleukin-1 beta (IL-1) induced a time-dependent increase in prostaglandin E2 (PGE2) formation and release into the extracellular medium. This increase was associated with a dramatic upregulation of the steady-state levels of mRNA for the prostaglandin endoperoxide synthetase (PES)-2 gene transcript as demonstrated by Northern analysis. In contrast, there did not appear to be a significant increase in the mRNA levels for a 2.8-kb transcript for the PES-1 gene. At 18 h of exposure to IL-1, the steady-state level of message for PES-2 remained elevated at 50% of the 2-h time point. Culturing the cells in the presence of cycloheximide and IL-1 demonstrated a superinduction of the PES-2 message without any change in PES-1 message. The tumor-promoting phorbol ester, phorbol myristate acetate (PMA), was also associated with an upregulation of the message for the PES-2 gene and did not influence the levels of the message for the PES-1 gene as demonstrated by Northern analysis. Dexamethasone (Dex) inhibited to control levels the induction by PMA, but the induction of the message by IL-1 was only inhibited 30%. Despite 70% of the message being present by 2 h of induction, Dex was capable of totally inhibiting the inductive effect of IL-1 with respect to PGE2 biosynthesis. Immunocytochemical studies demonstrated a dramatic induction of PES-2 protein by IL-1, which was inhibited by Dex. The data suggest that Dex inhibits the translation of the PES-2 protein. | lld:pubmed |
| pubmed-article:8304483 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304483 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304483 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8304483 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304483 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8304483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8304483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:8304483 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8304483 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8304483 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:8304483 | pubmed:issn | 0002-9513 | lld:pubmed |
| pubmed-article:8304483 | pubmed:author | pubmed-author:MorrisonA RAR | lld:pubmed |
| pubmed-article:8304483 | pubmed:author | pubmed-author:RzymkiewiczDD | lld:pubmed |
| pubmed-article:8304483 | pubmed:author | pubmed-author:LeingangKK | lld:pubmed |
| pubmed-article:8304483 | pubmed:author | pubmed-author:BairdNN | lld:pubmed |
| pubmed-article:8304483 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8304483 | pubmed:volume | 266 | lld:pubmed |
| pubmed-article:8304483 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8304483 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8304483 | pubmed:pagination | F39-45 | lld:pubmed |
| pubmed-article:8304483 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:8304483 | pubmed:meshHeading | pubmed-meshheading:8304483-... | lld:pubmed |
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| pubmed-article:8304483 | pubmed:meshHeading | pubmed-meshheading:8304483-... | lld:pubmed |
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| pubmed-article:8304483 | pubmed:meshHeading | pubmed-meshheading:8304483-... | lld:pubmed |
| pubmed-article:8304483 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8304483 | pubmed:articleTitle | Regulation of prostaglandin endoperoxide synthase gene expression in rat mesangial cells by interleukin-1 beta. | lld:pubmed |
| pubmed-article:8304483 | pubmed:affiliation | Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110. | lld:pubmed |
| pubmed-article:8304483 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8304483 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:8304483 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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