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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-3-8
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pubmed:databankReference |
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pubmed:abstractText |
Retrovirus infection is initiated by binding of the viral envelope glycoprotein to a cell-surface receptor. The envelope proteins of type C retroviruses of mammals demonstrate similarities in structural organization and protein sequence. These similarities suggest the possibility that retroviruses from different interference groups might use related proteins as receptors, despite the absence of any relationship between retrovirus receptors isolated to date. To investigate this possibility, we have identified a human cDNA clone encoding a protein closely related to the receptor for gibbon ape leukemia virus and have found that it functions as the receptor for the amphotropic group of murine retroviruses. Expression of this protein (GLVR-2) is likely to be a requirement for infection of human cells by amphotropic retroviral vectors for purposes of gene therapy.
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1309898,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1310758,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1321266,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1531369,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1589762,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1656098,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1672162,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1691887,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-1717711,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-2078500,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-2153240,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-2159567,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-2541919,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-2631796,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-271968,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-2991590,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-3080518,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-3086883,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-3099292,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-3201246,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-3323803,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-3600789,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-4287698,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-566388,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-6083454,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-6096719,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-6258156,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-6310150,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-6330990,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-6609441,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-8278411,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-8380453,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-8383231,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-8402881,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-8411375,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8302848-8445722
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
http://linkedlifedata.com/resource/pubmed/chemical/Carrier Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/DNA, Complementary,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Glycoproteins,
http://linkedlifedata.com/resource/pubmed/chemical/Membrane Proteins,
http://linkedlifedata.com/resource/pubmed/chemical/Receptors, Virus,
http://linkedlifedata.com/resource/pubmed/chemical/SLC20A2 protein, human,
http://linkedlifedata.com/resource/pubmed/chemical/Sodium-Phosphate Cotransporter...,
http://linkedlifedata.com/resource/pubmed/chemical/ecotropic murine leukemia virus...,
http://linkedlifedata.com/resource/pubmed/chemical/leukemia virus receptor, gibbon ape
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pubmed:status |
MEDLINE
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pubmed:month |
Feb
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pubmed:issn |
0027-8424
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pubmed:author |
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pubmed:issnType |
Print
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pubmed:day |
1
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pubmed:volume |
91
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pubmed:geneSymbol |
Ram-1
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
1168-72
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pubmed:dateRevised |
2009-11-18
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pubmed:meshHeading |
pubmed-meshheading:8302848-Humans,
pubmed-meshheading:8302848-Animals,
pubmed-meshheading:8302848-Mice,
pubmed-meshheading:8302848-Cricetinae,
pubmed-meshheading:8302848-Membrane Proteins,
pubmed-meshheading:8302848-Retroviridae,
pubmed-meshheading:8302848-Amino Acid Sequence,
pubmed-meshheading:8302848-Chromosome Mapping,
pubmed-meshheading:8302848-Leukemia Virus, Murine,
pubmed-meshheading:8302848-CHO Cells,
pubmed-meshheading:8302848-Cell Line,
pubmed-meshheading:8302848-Molecular Sequence Data,
pubmed-meshheading:8302848-Carrier Proteins,
pubmed-meshheading:8302848-3T3 Cells,
pubmed-meshheading:8302848-Cloning, Molecular,
pubmed-meshheading:8302848-Sequence Homology, Amino Acid,
pubmed-meshheading:8302848-Receptors, Virus,
pubmed-meshheading:8302848-DNA, Complementary,
pubmed-meshheading:8302848-Membrane Glycoproteins,
pubmed-meshheading:8302848-Genetic Vectors,
pubmed-meshheading:8302848-Gene Expression,
pubmed-meshheading:8302848-Sodium-Phosphate Cotransporter Proteins, Type III,
pubmed-meshheading:8302848-Leukemia Virus, Gibbon Ape
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