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| Predicate | Object |
|---|---|
| rdf:type | |
| lifeskim:mentions | |
| pubmed:issue |
4
|
| pubmed:dateCreated |
1994-3-4
|
| pubmed:abstractText |
The influence of donor age on the outcome of kidney transplantation (TX) was evaluated in 169 patients who received a primary cadaver kidney transplant at our center between September 16, 1984, and December 31, 1990. All the patients received cyclosporin A as part of the immunosuppressive protocol. Patients were grouped according to donor age: low donor age (LDA; donor age range 12-25 years), medium donor age (MDA; range 26-50 years) and higher donor age (HDA; range 51-66 years). There were no differences between groups in graft and patient survival, and multivariate analysis did not show any effect of donor age on those parameters. Proteinuria/day and number of rejection episodes did not differ between groups either. Immediate diuresis was more frequent in group LDA than in the other two groups (73.8, 54.7 and 57.1%, respectively; p < 0.05) and immediate diuresis resulted as a weak positive prognostic factor for graft outcome at multivariate analysis (p = 0.05). At both univariate and multivariate analyses, donor age resulted inversely correlated with creatinine clearance (CCr) at every period after TX but the 5th year, with r2 from 0.12 to 0.23 (p < 0.01). The LDA group had significantly better CCr than the HDA group at every period after TX but for the 5th year (the MDA group behaved intermediately).(ABSTRACT TRUNCATED AT 250 WORDS)
|
| pubmed:language |
eng
|
| pubmed:journal | |
| pubmed:citationSubset |
IM
|
| pubmed:chemical | |
| pubmed:status |
MEDLINE
|
| pubmed:issn |
0028-2766
|
| pubmed:author | |
| pubmed:issnType |
Print
|
| pubmed:volume |
65
|
| pubmed:owner |
NLM
|
| pubmed:authorsComplete |
Y
|
| pubmed:pagination |
541-8
|
| pubmed:dateRevised |
2006-11-15
|
| pubmed:meshHeading |
pubmed-meshheading:8302407-Adolescent,
pubmed-meshheading:8302407-Adult,
pubmed-meshheading:8302407-Age Factors,
pubmed-meshheading:8302407-Aged,
pubmed-meshheading:8302407-Aging,
pubmed-meshheading:8302407-Cadaver,
pubmed-meshheading:8302407-Child,
pubmed-meshheading:8302407-Cyclosporine,
pubmed-meshheading:8302407-Female,
pubmed-meshheading:8302407-Graft Survival,
pubmed-meshheading:8302407-Humans,
pubmed-meshheading:8302407-Immunosuppression,
pubmed-meshheading:8302407-Kidney,
pubmed-meshheading:8302407-Kidney Transplantation,
pubmed-meshheading:8302407-Male,
pubmed-meshheading:8302407-Middle Aged,
pubmed-meshheading:8302407-Multivariate Analysis,
pubmed-meshheading:8302407-Tissue Donors
|
| pubmed:year |
1993
|
| pubmed:articleTitle |
Influence of donor age on cadaver kidney graft function and survival: univariate and multivariate analyses.
|
| pubmed:affiliation |
Transplant Center, Treviso General Hospital, Italy.
|
| pubmed:publicationType |
Journal Article,
Comparative Study
|