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pubmed-article:8301881pubmed:abstractTextTo evaluate the effect of pravastatin, an HMG-CoA reductase inhibitor, on sleep, the drug or a placebo was administered to 5 healthy adults for 16 days by the double-blind method. Pravastatin caused no changes in sleep parameters. This indicates that it had no effect on human sleep for the following possible reasons: Being hydrophilic, the drug does not readily cross the blood-brain barrier. It does not inhibit prostaglandin D2 synthase, a possible sleep-inducing substance. It was thought that a decrease in the total cholesterol level in the blood has no effect on sleep in healthy adults.lld:pubmed
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pubmed-article:8301881pubmed:articleTitleEffect of pravastatin on human sleep.lld:pubmed
pubmed-article:8301881pubmed:affiliationDepartment of Neuropsychiatry, Yamanashi Medical University, Japan.lld:pubmed
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