Linked Life Data

8301881

Source:http://linkedlifedata.com/resource/pubmed/id/8301881

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
3
pubmed:dateCreated
1994-3-9
pubmed:abstractText
To evaluate the effect of pravastatin, an HMG-CoA reductase inhibitor, on sleep, the drug or a placebo was administered to 5 healthy adults for 16 days by the double-blind method. Pravastatin caused no changes in sleep parameters. This indicates that it had no effect on human sleep for the following possible reasons: Being hydrophilic, the drug does not readily cross the blood-brain barrier. It does not inhibit prostaglandin D2 synthase, a possible sleep-inducing substance. It was thought that a decrease in the total cholesterol level in the blood has no effect on sleep in healthy adults.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Sep
pubmed:issn
0912-2036
pubmed:author
pubmed:issnType
Print
pubmed:volume
47
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
643-6
pubmed:dateRevised
2004-11-17
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Effect of pravastatin on human sleep.
pubmed:affiliation
Department of Neuropsychiatry, Yamanashi Medical University, Japan.
pubmed:publicationType
Journal Article, Clinical Trial, Randomized Controlled Trial