Linked Life Data

8299603

Source:http://linkedlifedata.com/resource/pubmed/id/8299603

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-3-4
pubmed:abstractText
Ten healthy sedentary subjects [age, 27.5 (SD 3.5) years; height, 180 (SD 5) cm; mass, 69.3 (SD 6.3) kg] performed two periods of maximal incremental graded cycle ergometer exercise in a supine position. Randomly ordered and using an open spirometric system, one exercise was carried out during normoxia [maximal oxygen consumption (VO2max) = 38.6 (SD 3.5) ml.min-1.kg-1; maximal blood lactate concentration, 9.86 (SD 1.85) mmol.l-1; test duration, 22.6 (SD 2.7) min], the other during hypoxia [VO2max = 33.2 (SD 3.2) ml.min-1.kg-1; maximal blood lactate concentration, 10.38 (SD 2.02) mmol.l-1; test duration, 19.7 (SD 2.8) min]. At rest, immediately (0 p) and 60 min (60 p) after exercise, counts of leucocyte subpopulations (flow cytometry), cortisol and catecholamine concentrations were determined. At 0 p in contrast to normoxia, during hypoxia there was no significant increase of granulocytes. There were no significant differences between normoxia and hypoxia in the increases from rest to 0 p in counts of monocytes, total lymphocytes and lymphocyte subpopulations [clusters of differentiation (CD), CD3+, CD4+CD45RO-, CD4+CD45RO+, CD8+CD45RO-, CD8+CD45RO+, CD3+HLA-DR+, CD3-CD16/CD56+, CD3+CD16/CD56+, CD19+] as well as adrenaline, noradrenaline and cortisol concentrations. The counts of CD3-CD16/CD56(+)- and CD8+CD45RO(+)-cells increased most. At 60 p, CD3-CD16/CD56+ and CD3+CD16/CD56(+)-cell counts were below pre-exercise levels and under hypoxia slightly but significantly lower than under normoxia. We concluded that the exercise-induced mobilization and redistribution of most leucocyte and lymphocyte subpopulations were unimpaired under acute hypoxia at sea level. Reduced increases of granulocyte counts during the study and reduced cell numbers of natural killer cells and cytotoxic, not major histocompatibility complex-restricted T-cells, only indicated marginal effects on the immune system.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:issn
0301-5548
pubmed:author
pubmed:issnType
Print
pubmed:volume
67
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
348-53
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Circulating leucocyte subpopulations in sedentary subjects following graded maximal exercise with hypoxia.
pubmed:affiliation
Institute of Sports and Performance Medicine, University of Saarland, Saarbrücken, Germany.
pubmed:publicationType
Journal Article, Clinical Trial, Comparative Study, Randomized Controlled Trial