Linked Life Data

829902

Source:http://linkedlifedata.com/resource/pubmed/id/829902

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
11
pubmed:dateCreated
1978-10-25
pubmed:abstractText
The BAB/14 (BALB/c. C57BL/Ka-Ig-1b/HZ) congenic mouse strain was found to respond to (4-hydroxy-3-nitrophenyl)acetyl (NP)-chicken globulin immunization with nonheteroclitic anti-NP antibodies as does the BALB/c inbred partner strain. This is in contrast to the heteroclitic anti-NP response of the C57BL/Ka allotype donor strain and indicates that the allotype linked VH-NP gene was inherited with the VH-DEX gene from BALB/C rather than with the allotype genes from C57BL/Ka. This verifies the interpretation of BAB/14 as an immunoglobulin gene recombinant. Two recombinants between VH-DEX and Ig-1 allogype genes have been found among 554 chromosomes tested yielding a recombination frequency of 0.4%. Analysis of the BAB/14 recombinant showed that this crossover occurred between VH genes implying that VH genes and CH genes are not organized in separate clusters separated by a larger spacer region but are contiguous. Analysis of the recombination frequencies indicates that the total number of VH genes must be at least 50.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
0014-2980
pubmed:author
pubmed:issnType
Print
pubmed:volume
5
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
778-81
pubmed:dateRevised
2011-11-17
pubmed:meshHeading
pubmed:year
1975
pubmed:articleTitle
Genetics of mouse antibodies. II. Recombination between VH genes and allotype.
pubmed:publicationType
Journal Article, Research Support, U.S. Gov't, P.H.S.