Linked Life Data

8298506

Source:http://linkedlifedata.com/resource/pubmed/id/8298506

Statements in which the resource exists as a subject.
PredicateObject
rdf:type
lifeskim:mentions
pubmed:issue
4
pubmed:dateCreated
1994-3-8
pubmed:abstractText
Much of the oxidative damage to human LDL in vivo may lead to only minimal changes in the chemical properties of the LDL. Therefore, chemical changes were evaluated during the initial 3 hours of oxidative attack on human LDL with 5 microM Cu. HPLC analyses were calibrated with a conjugated-diene internal standard. Cholesterol-linoleate-hydroperoxide (Chol-18:2-OOH) accumulated much more rapidly than alpha-tocopherol was lost. Although large amounts of cholesterol arachidonate were destroyed, diene-containing oxidation products of this lipid were not identified by HPLC analysis. Phosphatidyl-choline-hydroperoxides accumulated much more slowly than chol-18:2-OOH. beta-carotene was oxidized relatively slowly, but lycopene was destroyed almost as fast as alpha-tocopherol. The preferential accumulation of chol-18:2-OOH is consistent with a model in which alpha-tocopherol is localized to the surface of the LDL particle, providing minimal protection to hydrophobic components in the core of the LDL.
pubmed:language
eng
pubmed:journal
pubmed:citationSubset
IM
pubmed:chemical
pubmed:status
MEDLINE
pubmed:month
Nov
pubmed:issn
1039-9712
pubmed:author
pubmed:issnType
Print
pubmed:volume
31
pubmed:owner
NLM
pubmed:authorsComplete
Y
pubmed:pagination
777-88
pubmed:dateRevised
2006-11-15
pubmed:meshHeading
pubmed:year
1993
pubmed:articleTitle
Chemical changes during the early phase of in vitro oxidative damage to human LDL.
pubmed:affiliation
Department of Food Science and Technology, University of California, Davis 95616.
pubmed:publicationType
Journal Article, In Vitro, Research Support, Non-U.S. Gov't