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rdf:type |
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lifeskim:mentions |
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pubmed:issue |
3
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pubmed:dateCreated |
1994-3-7
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pubmed:abstractText |
In this article, we explore the hypothesis that tumor cells can escape recognition by CD8+ T cells via deficiencies in antigen processing and presentation. Aspects of the molecular and cellular biology of major histocompatibility complex class I are reviewed. Evidence for histology-specific molecular mechanisms in the antigen-processing and -presentation deficiencies observed in some human and murine tumors is presented. Mechanisms identified include down-regulation of antigen processing, loss of functional beta 2-microglobulin, and deletion of specific alpha-chain alleles. Finally, we discuss studies using an antigen-presentation-deficient mouse tumor as a model for the immunogenetherapy of an antigen-presentation deficiency.
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pubmed:grant |
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pubmed:commentsCorrections |
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1299222,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1386516,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1436094,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1516027,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1588273,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1684779,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1700304,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1709722,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1786080,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1840703,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1853786,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1898655,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1900079,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-1907999,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2123742,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2201309,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2321019,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2326647,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2469442,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2474372,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2580935,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-2666863,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-3108401,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-3264384,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-3289573,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-3310381,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-3489291,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-6440030,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-8426105,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-8432988,
http://linkedlifedata.com/resource/pubmed/commentcorrection/8297900-8459226
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pubmed:language |
eng
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pubmed:journal |
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pubmed:citationSubset |
IM
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pubmed:chemical |
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pubmed:status |
MEDLINE
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pubmed:month |
Oct
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pubmed:issn |
1067-5582
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pubmed:author |
|
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pubmed:issnType |
Print
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pubmed:volume |
14
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pubmed:owner |
NLM
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pubmed:authorsComplete |
Y
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pubmed:pagination |
182-90
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pubmed:dateRevised |
2011-9-26
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pubmed:meshHeading |
pubmed-meshheading:8297900-Animals,
pubmed-meshheading:8297900-Antigen-Antibody Reactions,
pubmed-meshheading:8297900-Antigens, Neoplasm,
pubmed-meshheading:8297900-Combined Modality Therapy,
pubmed-meshheading:8297900-Gene Therapy,
pubmed-meshheading:8297900-Histocompatibility Antigens Class I,
pubmed-meshheading:8297900-Humans,
pubmed-meshheading:8297900-Immunotherapy,
pubmed-meshheading:8297900-Interferon-gamma,
pubmed-meshheading:8297900-Mice,
pubmed-meshheading:8297900-T-Lymphocytes, Regulatory
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pubmed:year |
1993
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pubmed:articleTitle |
Molecular mechanisms used by tumors to escape immune recognition: immunogenetherapy and the cell biology of major histocompatibility complex class I.
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pubmed:affiliation |
Division of Cancer Treatment, National Cancer Institute, National Institutes of Health, Bethesda, Maryland 20892.
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pubmed:publicationType |
Journal Article,
Review
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