| pubmed-article:8297719 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C0007134 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C0796477 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C1520354 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C0086345 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C1261322 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C0205422 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C0002085 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C0936012 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C1517945 | lld:lifeskim |
| pubmed-article:8297719 | lifeskim:mentions | umls-concept:C1553568 | lld:lifeskim |
| pubmed-article:8297719 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:8297719 | pubmed:dateCreated | 1994-3-7 | lld:pubmed |
| pubmed-article:8297719 | pubmed:abstractText | To investigate the role of tumour-suppressor genes on the short arm of chromosome 3 in the mechanism of tumorigenesis in non-familial renal cell carcinoma, we analysed 55 paired blood-tumour DNA samples for allele loss on chromosome 3p and in the region of known or putative tumour-suppressor genes on chromosomes 5, 11, 17 and 22. Sixty-four per cent (35/55) of informative tumours showed loss of heterozygosity (LOH) of at least one locus on the short arm of chromosome 3, compared with only 13% at the p53 tumour-suppressor gene and 6% at 17q21. LOH at chromosome 5q21 and 22q was uncommon (2-3%). Detailed analysis of the regions of LOH on chromosome 3p suggested that, in addition to the VHL gene in chromosome 3p25-p26, mutations in one or more tumour-suppressor genes in chromosome 3p13-p24 may be involved in the pathogenesis of sporadic renal cell carcinoma (RCC). We also confirmed previous suggestions that chromosome 3p allele loss is not a feature of papillary RCC (P < 0.05). | lld:pubmed |
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| pubmed-article:8297719 | pubmed:language | eng | lld:pubmed |
| pubmed-article:8297719 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:8297719 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:8297719 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:8297719 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:8297719 | pubmed:issn | 0007-0920 | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:RichardsF MFM | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:Ferguson-Smit... | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:FosterKK | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:JonesM HMH | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:AffaraN ANA | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:MaherE RER | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:BentleyEE | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:CairnsPP | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:HetheringtonJ... | lld:pubmed |
| pubmed-article:8297719 | pubmed:author | pubmed-author:CrosseyP APA | lld:pubmed |
| pubmed-article:8297719 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:8297719 | pubmed:volume | 69 | lld:pubmed |
| pubmed-article:8297719 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:8297719 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:8297719 | pubmed:pagination | 230-4 | lld:pubmed |
| pubmed-article:8297719 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:8297719 | pubmed:year | 1994 | lld:pubmed |
| pubmed-article:8297719 | pubmed:articleTitle | Molecular genetic investigation of sporadic renal cell carcinoma: analysis of allele loss on chromosomes 3p, 5q, 11p, 17 and 22. | lld:pubmed |
| pubmed-article:8297719 | pubmed:affiliation | Department of Pathology, Cambridge University, UK. | lld:pubmed |
| pubmed-article:8297719 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:8297719 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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